黏膜地址素细胞黏附分子-1的表达与胃癌的关系

Relationship between immunoreactivity of mucosal addressin cell adhesion molecule-1 and gastric cancer

目的探讨黏膜地址素细胞黏附分子-1(MadCAM-1)的表达与胃癌发生的关系。方法采用免疫组织化学SP法检测50例行胃癌根治术所收集的癌组织、癌旁组织和正常胃黏膜组织中MadCAM-1的表达情况。结果MadCAM-1表达率在正常胃黏膜、癌旁组织和癌组织中分别为78%(39/50)、64%(32/50)和40%(20/50)。癌组织中的阳性表达率明显低于正常组织(P<0.01)和癌旁组织(P<0.01);而正常组织与癌旁组织之间差异无统计学意义(P>0.05);MadCAM-1阳性表达率低年龄组(<45岁)表达低于高年龄组(>45岁,P<0.05);MadCAM-1的阳性表达率与Borrmarn分型、肿瘤部位、肿瘤大小及癌细胞的浸润深度和分化程度无关(P>0.05)。结论MadCAM-1参与肿瘤局部免疫过程,与胃癌发生有关。

Objective To investigate the relationship between immunoreactivity of mucosal addressin cell adhesion molecule-1 （MadCAM-1） and the development of gastric cancer. Methods The expressions of MadCAM-1 were detected by immunohistochemical SP method in gastric carcinomas, normal gastric tissues and cancer-adjacent tissues of 50 collected specimens with radical resection of gastric carcinomas. Results The expressions of MadCAM-1 were 78% （39/50）, 64% （32/50） and 40% （20/50） respectively in normal gastric mucosae, cancer-adjacent tissues and gastric carcinoma tissues. The expression rate of MadCAM-1 was lower in gastric carcinoma tissues than in normal gastric mucosae and cancer-adjacent tissues （P 〈0.01）, and no significant difference between normal gastric mucosae and cancer-adjacent tissues was found （P 〉0.05）. The expression rate of MadCAM-1 was lower in young group （〈45 y） than in old group （〉45 y, F 〈0.05）. The expression of MadCAM-1 showed no correlation with Borrmarn type, tumor location, tumor size and the differentiation and infiltration grade of gastric carcinoma （P 〉0.05）.Conclusion MadCAM-1 may be involved in the local immunity and the development of gastric carcinoma.