期刊文献+

P16^(INK4A)在宫颈癌及癌前病变的表达及临床意义 被引量:2

下载PDF
导出
摘要 采用免疫组织化学技术SP法检测31例宫颈癌(UCC)、31例宫颈上皮内瘤变(CIN)、10例宫颈炎标本中P16INK4A表达情况。发现P16INK4A在上述3种组织中均有表达,且表达阳性率逐渐降低,分别为100.00%、74.19%、30.00%,且其表达与UCC病理分级和肌层浸润程度有关。提示P16INK4A的检测可提高对宫颈癌前变及UCC的早期诊断率。
出处 《山东医药》 CAS 北大核心 2008年第41期75-76,共2页 Shandong Medical Journal
  • 相关文献

参考文献3

  • 1Uozaki H, Horluehi H, lshida T, related proteins (metallothioneins et al. Overexpression of resistanceglutathione-S-transferase pi, heat shock protein 27, and lung resistance-related protein) in osteosarcoma. Relationship with poor prognosis [J].Cancer, 1997,79(12) : 2336-2344.
  • 2Murphy N, Ring M, Killalea AG, et al. P16INK4A as a marker for cervical dyskaryosis: C1N and cGIN in cervical biopsies and ThinPrep smears [J]. J Clin Pathol, 2003,56( 1 ) :56-63.
  • 3Hu L, Guo M, He Z, et al. Human papillomavirus genotyping and P16INK4A expression in cervical intraepithelial neoplasia of adolescents [ J ]. Mod Pathol, 2005,18 (2) :267-273.

同被引文献27

  • 1Uozaki H,Horiuchi H,Ishida T,et al.Overexpression of resistance-related proteins (metallothioneins,glutathione-S-transferase pi,heat shock protein 27,and lung resistance-related protein) in osteosarcoma.Relationship with poor prognosis[J].Cancer,1997,79(12):2336-2344.
  • 2Khoo CM,Carrasco DR,Bosenberg MW,et al.Ink4a/Arftumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse[J].Proc Natl Acad Sci USA,2007,104(10):3931-3936.
  • 3Wang JL,Zheng BY,Li XD,et al.Predictive significance of the alterations of p16INK4a,p14ARF,p53,and proliferating cell nuclear antigen expression in the progression of cervical cancer[J].Clin Cancer Res,2004,10(7):2407-2414.
  • 4O'Neill CJ,McCluggage WG.p16 expression in the female genital tract and its value in diagnosis[J].Adv Anat Pathol,2006,13(1):8-15.
  • 5Ishikawa M,Fujii T,Saito M,et al.Overexpression of p16INK4a as an indicator for human papillomavirus oncogenic activity in cervical squamous neoplasia[J].Int J Gynecol Cancer,2006,16(1):347-353.
  • 6Zaffaroni N,Costa A,Pennati M,et al.Survivin is highly expressed and promotes cell survival in malignant peritoneal mesothelioma[J].Cell Oncol,2007,29 (6):453-466.
  • 7Stauber RH,Mann W,Knauer SK.Nuclear and cytoplasmic survivin:molecular mechanism,prognostic,and therapeutic potential[J].Cancer Res,2007,67 (13):5999-6002.
  • 8Kim HS,Shiraki K,Park SH,et al.Expression of Survivin in CIN and invasive squamous cell carcinoma of uterine cervix[J].Anticancer Res,2002,22(2A):805-808.
  • 9Magali E,David C,Norma H,et al.Inhibitors of apoptosis proteins in human cervical cancer[J].BMC Cancer,2006,6(45):1471-2407.
  • 10Suzuki A,Hayashida M,Ito T,et al.Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation[J].Oncogene,2000;19(29):3225-3234.

引证文献2

二级引证文献7

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部