摘要
目的:评价普伐他汀对高血压患者脉压和动脉弹性的影响。方法:选择54例正在规律服用降压药物治疗并且脉压≥60mmHg的高血压患者,随机分成治疗组和对照组,每组各27例,治疗组在原降压药物的基础上加服普伐他汀(20mg/d),对照组则继续服用原降压药物不变,在治疗前及治疗16周以后分别检测患者的血压、大动脉和小动脉弹性指数(C1和C2)。结果:普伐他汀组治疗后的收缩压(SBP)、脉压(PP)和C2较对照组有明显改善(P<0.05),C1则无显著改变(P>0.05)。结论:普伐他汀能明显改善高血压患者的小动脉弹性,从而起到降低脉压的作用。
Objective: To evaluate the effect of pravastatin on pulse pressure and arterial elasticity of patients with essential hypertension. Methods: 54 patients with pulse pressure being 60mmHg or above , were randomly divided into two groups: treatment group(n=27) was given pravastatin (20mg/d)and unchanged in the control group(n=27)on the basis of the original treatment for 16 weeks. Brachial blood pressure , large and small arterial elastic indexes (Cland C2)were measured before and after treatment. Results: In pravastatin group , systolic blood pressure and pulse pressure were decreased significantly(P〈0. 05), C2 was increased (P〈0.05), while no change for C1 was shown(P〉0. 05). Conclusion: Pravastatin might reduce pulse pressure through improvement of small arterial elasticity in hypertensives.
出处
《数理医药学杂志》
2008年第6期683-685,共3页
Journal of Mathematical Medicine
关键词
普伐他汀
高血压
脉压
动脉弹性
pravastatin
hypertension
pulse pressure
arterial elasticity