小剂量戊酸雌二醇结合牡蛎碳酸钙咀嚼片治疗绝经后骨质疏松症的研究

The research of small dose of estradiol valerate combination of ovseter shell calcium chewable tablets treatment of postmenopausal osteoporosis

目的观察小剂量戊酸雌二醇结合牡蛎碳酸钙咀嚼片（盖天力）治疗绝经后骨质疏松症的临床疗效和安全性。方法32例绝经后骨质疏松症患者口服戊酸雌二醇1mg／d，盖天力150mg，每日3次，每个月后半程加服醋酸甲羟孕酮4mg／d，治疗6个月。结果治疗后L1-4。及左侧股骨骨密度均有明显提高（P〈0．05）。治疗后27例（84．4％）患者自觉腰背部及关节疼痛明显好转或消失，生活能自理，并能参加正常社会活动。4例患者治疗3个月内有少许不规则阴道出血，加服醋酸甲羟孕酮后好转，3例患者出现轻至中度的乳腺肿胀，1例患者出现白带增多，但均很快自然好转。结论小剂量戊酸雌二醇结合盖天力治疗绝经后骨质疏松症可缓解疼痛，提高骨密度，预防骨丢失，效果明显，不良反应少。

Objective To observe the efficacy and safety of small dose of estradiol valerate combination of ovseter shell calcium chewable tablets treatment of postmenopausal osteoporosis. Methods Thirty-two patients with postmenopausal osteoporosis with oral estradiol valerate 1 mg/d, ovseter shell calcium chewable tablets 150 mg, three times one day, month after serving 15 days added medroxyprogesterone acetate 4 mg/d, at least were observed the course of six months. Results After treatment, bone density of L1-4 and left femur was increased significantly （P〈 0.05）. Twenty-seven cases （84.4%） with six months treatment felt the pain in back and joints improved or disappeared, they could take care of themselves and take part in normal social activities. Four cases of patients within 3 months had some irregular vaginal bleeding, and service improved after adding medroxyprogesterone acetate, 3 cases of patients with a mild to moderate expansion of mammary gland, one patient appeared leucorrhea increased, but soon turned for better. Conclusions Small dose of estradiol valerate combination of ovseter shell calcium chewable tablets treatment of postmenopausal osteoporosis has the effect of releasing pain, increasing bone density, preventing bone loss, evident result and fewer untoward reaction.