Synthesis of Heterocycle Compounds Containing Two Pyridazinone Units

Synthesis of Heterocycle Compounds Containing Two Pyridazinone Units

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摘要 Four novel compounds containing two pyridazinone units attached to one benzene or pyridine ring, protected and deprotected 1,5-di[3（2H）-pyridazinon-6-yl]benzene and 2,6-di[3（2H）-pyridazinon-6-yl]pyridine were synthesized in eight steps, which provided a useful method for the preparation of pyridazinone derivatives via the Stetter and cyclization reactions. Their structures were characterized by ^1H NMR, ^13C NMR, and HRMS. Four novel compounds containing two pyridazinone units attached to one benzene or pyridine ring, protected and deprotected 1,5-di[3（2H）-pyridazinon-6-yl]benzene and 2,6-di[3（2H）-pyridazinon-6-yl]pyridine were synthesized in eight steps, which provided a useful method for the preparation of pyridazinone derivatives via the Stetter and cyclization reactions. Their structures were characterized by ^1H NMR, ^13C NMR, and HRMS.

作者 XIN Bing-wei

机构地区 Department of Chemistry

出处《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2008年第6期739-742,共4页 高等学校化学研究（英文版）

基金 Support by the National Natural Science Foundation of China(No.20571063)

关键词 1 5-Di[3（2H）-pyridazinon-6-yl]benzene 2 6-Di[3（2H）-pyridazinon-6-yl]pyridine PYRIDAZINONE Stetter reaction Antitumor compound 1,5-Di[3（2H）-pyridazinon-6-yl]benzene 2,6-Di[3（2H）-pyridazinon-6-yl]pyridine Pyridazinone Stetter reaction Antitumor compound

分类号 O6 [理学—化学]

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Chemical Research in Chinese Universities

2008年第6期

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Synthesis of Heterocycle Compounds Containing Two Pyridazinone Units

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