解毒通络保肾胶囊对糖尿病肾病大鼠血糖及肾功能的影响

Impacts of Jie Du Tong Luo Bao Shen Jiaonang on Plasma Glucose and Renal Function in Rats with Diabetic Renal Disease

目的研究通络保肾胶囊对糖尿病大鼠肾脏损害的保护作用。方法将36只大鼠随机分成正常对照组、糖尿病模型组与解毒通络保肾胶囊组3组,每组12只,除正常对照组外,其余两组动物制成糖尿病肾病模型。正常对照组、糖尿病模型组灌胃等体积生理盐水;解毒通络保肾胶囊组每日上午灌服解毒通络保肾胶囊浓缩液。结果解毒通络保肾胶囊组大鼠的一般情况明显优于糖尿病肾病模型组与正常对照组有区别,但无显著性差异(P>0.05)。在降低血糖、血脂,改善肾功能等方面解毒通络保肾胶囊组明显优于糖尿病模型组。结论解毒通络保肾胶囊能够改善实验性糖尿病肾病大鼠一般状况,调节糖脂代谢,对糖尿病肾病大鼠肾脏损害有一定的保护作用。

Objective To study the protection of Jie Du Tong Luo Bao Shen Jiaonang （capsule for detoxification,promotion of circulation and protection of kidney）（Capsule）on renal injury in diabetic rats. Methods 36 rats were randomized into normal control group, diabetic model group and Capsule group, 12 rats in each one. Except normal control group, the animals in the other two groups were prepared as the models of diabetic renal disease. In normal control group and diabetic model group,gastric perfusion was administered with normal saline of same volume. In Capsule group, the concentrating liquid of the Capsule was infused every morning. Results The general situations of rats in Capsule group were superior apparently to those in diabetic model group. But, no significant difference presented in comparison with normal control group （P〈0.05）. In the aspects of reducing glucose,reducing lipid and improving renal functions ,the outcomes in Capsule group were superior apparently to those in diabetic model group. Conclusion Jie Du Tong Luo Bao Shen Jiaonang improves the general state of experimental rats with diabetic renal disease,regulates glucose-lipid metabolism and presents a certain protection on renal damage in the rats with diabetic renal disease.