中药爽肤巾抗炎和收敛作用的实验研究

Anti-inflammatory and convergent effects of Shuangfujin

目的探讨中药爽肤巾对急性湿疹皮炎模型的抗炎、收敛作用。方法分别制备生理盐水组、3%硼酸溶液组、1∶50皮肤康洗液组和爽肤巾药液组。取昆明雄性小鼠40只,随机分为4组,根据二甲苯所致的小鼠耳肿胀度和厚度差分析每组药物的抗炎作用;取Wistar雄性大鼠40只,随机分为4组,根据磷酸组织胺对伊文氏蓝造模大鼠后背皮肤的色斑面积、皮肤厚度和皮肤溶解于丙酮溶液的光密度影响分析每组药物的收敛作用。结果爽肤巾组的抗炎作用最强(P<0.01),皮肤康洗液组的抗炎作用优于硼酸溶液组(P<0.05),生理盐水组抗炎作用最弱(P<0.01);爽肤巾组与皮肤康洗液组的收敛作用相近(P>0.05),爽肤巾组与皮肤康洗液组的收敛作用优于硼酸溶液组(P<0.05),生理盐水组收敛作用最弱(P<0.01)。结论中药爽肤巾对急性湿疹皮炎模型具有良好的抗炎、收敛作用。

Objective To discuss the anti-inflammatory and model of acute eczematous dermatitis. Methods The group of convergent effects of Shuangfujin on the normal saline, group of boric acid solution （3%）, group of Pifukang Lotion （ 1 ： 5 ） and group of Shuangfujin were established respectively. Kunming female mice （n = 40） were chosen and randomly divided into 4 groups. The anti-inflammatory effects in different groups were analyzed according to the swell degree and thickness difference of mouse ear induced by xylene. Wista male rats （n = 40） were chosen and randomly divided into 4 groups. The convergent effects in different groups were analyzed according to the splash area, skin thickness on rat back and optical density when skin dissolving in acetone solution induced by histamine phosphate after Evans blue modeling. Results The group of Shuangfujin had the highest anti-inflammatory effect （P 〈 0.01 ）. The group of Pifukang Lotion had higher solution （ P 〈 0.05 ）. The group of normal saline The group of Shuangfujin and group of Pifukang anti-inflammatory effect than the group of boric acid had the lowest anti-inflammatory effect （ P 〈 0.01 ）. Lotion had similar convergent effect （P 〉 0.05 ）, which was higher than that of the group of boric acid solution （P 〈 0. 05）. The group of normal saline had the lowest convergent effect （P 〈 0.01 ）. Conclusion Shuangfujin has good effects of anti-inflammation and convergence in the model of acute eczematous dermatitis.