实验性动物心肌缺血前后的高频心电图研究

Study of high frequency electrocardiogram in experimental dogs before and after myocardiol ischemia

我们用１０条狗制作心肌缺血模型，研究了正常、开胸、穿线和阻闭冠脉后即刻、３０′、６０′、９０′和１２０′时的体表常规心电图、心外膜电图和高频心电图的时域特点，发现对比正常和开胸时，阻闭冠脉３０′～６０′后切迹总数和异常切迹数明显增多（Ｐ＜０．０１），切迹高度明显增高（Ｐ＜０．０１），在ＱＲＳ综合波终末部上的切迹比例明显增高，ＱＲＳ综合波时限明显延长（Ｐ＜０．０１）和Ｒ波幅度明显降低（Ｐ＜０．０１）等．表明动态地观察和分析某些高频心电图的特征值，确实能比体表常规心电图更敏感地早期反映心肌缺血的微细变化，为此，我们认为在进一步制定适当的特征值和阈值之后，有望使高频心电图成为临床早期诊断心脏病的方法之一．

We used 10 dogs to make model of myocardial ischemia, and studed conventional electrocardiogram、epicardium electrogram and high frequency electrocardiogram during various period including normal, chest opened、myocardio threaded、ligaturing coronary artery、30′、60′、90′、120′ after ligaturing. We found that after 30′～60′ of ligaturing, comparing with normal, total and abnormal numbers of notches were significantly increased. Also in this period the proportion of notches and slures in terminal part of QRS complex was much higher and the time of QRS complex was obviously longer than normal and chest opened. The range of R wave was distinctly discreaded after chest opened. We think that in future with dynamicly analysing some characters of high frequency electrocardiogram can more sensitively be used to find early pathological changes in heart than conventional eletrocardiogram.