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血清可溶性尿激酶受体在急性髓细胞白血病中的表达及临床意义 被引量：5

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摘要 目的:探讨急性髓细胞白血病患者血清可溶性尿激酶受体(suPAR)表达和疾病病情及预后的关系。方法:采用酶联免疫吸附的方法检测60例急性髓细胞白血病患者和30例正常对照血清suPAR水平。结果:急性髓细胞白血病初治组、未缓解组及复发组的suPAR水平显著高于正常对照组(P<0.05),完全缓解组和正常对照组差异无统计学意义(P>0.05),未缓解组和复发组显著高于缓解组(P<0.05)。结论:检测急性髓细胞白血病患者suPAR水平对判断患者的临床状况及预后有一定指导意义。
作者 王娟 沈杰 李增杰 王庆 许卫星 王瑞环 张睿 刘春燕 苏国宏 马洪玉 范雅莉
机构地区 沧州市中心医院血液科
出处 《临床血液学杂志》 CAS 2008年第6期603-604,共2页 Journal of Clinical Hematology
关键词 白血病 SUPAR 预后
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献4

  • 1STEPHENS R W, NIELSEN H J,CHRISTENSEN I J,et al. Plasma urokinase receptor levels in patients with colorectal cancer: relationship to prognosis[J]. J Nat Cancer Inst, 1999,91 : 869 -- 874.
  • 2王娟,薛重重,杨丽萍,邢宪英,马洪玉,许卫星,沈杰,王庆,李静.CD87用于急性髓细胞白血病预后判断的临床研究[J].临床血液学杂志,2007,20(1):16-18. 被引量：5
  • 3COLEMAN J L,GEBBIA J A,BENACH J L,et al. Borrelia burgdorferi and other bacterial products induce expression and release of the urokinase receptor (CD87) [J]. J Immunol, 2001,166: 473 - 480.
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二级参考文献4

  • 1BENe M, CASTOLDI G L, KNAPP W, et al. A.& van't Veer M B, on behalf of the European Group for the Immunological Characterization of Leukemias,EGIL (1995) Proposals for the immunological classification of acute leukemias[J]. Leukemia, 9. 1783--1786.
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  • 4BESCHORNER R, SCHLUESENER H J, NGUYEN T D, et al, Lesion-associated accumulation of uPAR/CD87- expressing infiltrating granulocytes,activated microglial cells/macrophages and upregulation by endothelial cells following TBI and FCI in humans[J]. Neuropathol Appl Neurobiol, 2000, 26:522--527.

共引文献4

同被引文献50

  • 1李梦秋,陆茵.尿激酶型纤溶酶原激活物作用系统与肿瘤转移[J].实用肿瘤学杂志,2005,19(5):387-390. 被引量：3
  • 2张巧花,侯淑玲,李喜,贺建霞,王列样.非霍奇金淋巴瘤外周血尿激酶型纤溶酶原激活物及其受体测定的临床意义[J].白血病．淋巴瘤,2006,15(5):356-358. 被引量：1
  • 3陈金国.血清层粘连蛋白检测及临床意义[J].国外医学（临床生物化学与检验学分册）,1996,17(2):51-54. 被引量：28
  • 4STEPHENS R W,NIELSEN H J,CHRISTENSEN I J,et al.Plasma urokinase receptor levels in patients with colorectal cancer:relationship to prognosis[J].J Nat Cancer Inst,1999,91:869-874.
  • 5COLEMAN J L,GEBBIA J A,BENACH J L,et al.Borrelia burgdorferi and other bacterial products induce expression and release of the urokinase receptor (CD87)[J].J Immunol,2001,166:473-480.
  • 6RIGOLIN G M,TIEGHI A,CICCONE M,et al.Soluble urokinase-type plasminogen activator receptor (suPAR) as an independent factor predicting worse prognosis and extra bone marrow involvement in multiple myeloma patients[J].Br J Haematol,2003,120:953-959.
  • 7KOOLWIJK P,SIDENIUS N,PETERS E,et al.Proteolysis of the urokinase-type plasminogen activator receptor by metallopoteinase-12:implication forangiogenesis in fibrinmatrices[J].Blood,2001,97:3123-3131.
  • 8LUO L H,XU G B,LU X G.Detection and clinical significance of plasma urokinase-type plasminogen activator and its soluble receptor in patients with multiple myeloma[J].Zhejiang Da Xue Xue Bao Yi Xue Ban,2003,32:529-532.
  • 9Stephens RW,Nielsen HJ,Christensen IJ,et al.Plasma urokinase receptor levels in patients with colorectal cancer:relationship to prognosis.Nat Cancer Inst,1999,91:869-874.
  • 10Lanza F,Castoldi GL,Castagnari B,et al.Expression and functional role of urokinase-type plasminogen activator receptor in normal and acute leukemic cells.Br J Haematol,1998,103:110-123.

引证文献5

二级引证文献1

临床血液学杂志
2008年 第6期

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