2-乙酰基-7-甲胺基酮与TMB等取代芳香醛的反应

Condensation Reaction of 2 acetyl 7 methylaminotropone with Aromatic Aldehydes(TMB)

本文探讨了２－乙酰基－７－甲胺基卓酮与３，４，５－三甲氧基苯甲醛（ＴＭＢ）等取代芳香醛的羟醛缩合反应。２－乙酰基－７－甲胺基卓酮与ＴＭＢ、丁香醛、二溴醛等取代芳香醛进行反应分别生成了２－（３，４，５－三甲氧基）肉桂酰基－７－甲胺基卓酮；２－（４－羟基－３，５－二甲氧基）肉桂酰基－７－甲胺基卓酮；２－（４－羟基－３，５－二溴）肉桂酰基－７－甲胺基卓酮等三种尚未见文献报道的新化合物。它们的结构经红外光谱、核磁共振谱及元素分析得以证实。

Three new compounds were obtained by aldol condensation reaction of 2 acetyl 7 methylaminotropone with aromatic aldehydes such as 3,4,5 trimethoxybenzaldehyde,4 hydroxy 3,5 dimethoxybenzaldehyde,4 hydroxy 3,5 dibromobenzaldehyde in the presence of KOH.Their structures were confirmed by IR,H NMR and elementary analysis.