中药复方对实验性老年高脂血症LPO、SOD和红细胞免疫功能的影响

Effect of Chinese Complex Prescriptions to LPO, SOD and Erythrocyte Immunity of Experimental Senile Hyperliopoprotememia

运用高脂饲料喂饲老龄豚鼠造成“老年高脂血症”模型，观察补肾化痰祛瘀复方对实验动物的ＬＰＯ、ＳＯＤ、红细胞免疫粘附功能的影响及相关研究，并与肌醇烟酸酯比较。结果显示：实验性老年高脂血症可出现ＳＯＤ活性、红细胞Ｃ３ｂ受体（ＲＢＣ－Ｃ３ｂＲ）花环率下降，ＬＰＯ、红细胞免疫复合物（ＲＢＣ－ＩＣ）花环率增高，与对照组、造模前比较差异显著，有统计学意义。ＲＢＣ－Ｃ３ｂＲ和ＲＢＣ－ＩＣ花环率和超氧化物歧化酶（ＳＯＤ）活性分别呈正、负相关关系（Ｐ＜０．０１）；与过氧化脂质（ＬＰＯ）含量分别呈负、正相关关系（Ｐ＜０．０１）。提示中药复方可升高ＳＯＤ活性和ＲＢＣ－Ｃ３ｂＲ花环率、降低ＬＰＯ含量和ＲＢＣ－ＩＣ花环率，肌醇烟酸酯调节红细胞免疫功能的作用逊于该复方。

Senile hyperlipoprotememia caves moddle was made by feeding ketogenic fodder to observe the effect of Chinese complex prescriptions of invigorating the kidney, eliminating sputum and removing blood stasis to LPO, SOD and erythrocyte immunity of experimental animals and the result was compared with inositol nicotinate. The result showed that the activity of SOD, RBC-C 3bR of experimental senile hyperliopoprotememia decreased and LPO, RBC-IC increased. There were statistical differences between the moddle and normal senile animals(P<0.05). It is suggested that Chinese Complex Prescriptions could decrease the activity of SOD, RBC-C 3bR of experimental senile hyperliopoprotememia and increase LPO, RBC-IC and the immunitical function of the complex prescriptions and it was supior to inositol nicotinate.