骨髓间充质干细胞在特发性肺纤维化治疗中的潜在应用价值

Potential value of bone marrow mesenchymal stem cells in the treatment of idiopathic pulmonary fibrosis

特发性肺纤维化是一种弥漫性的肺纤维化病变。在目前,仍没有有效的治疗手段可以对该病进行干预,因此预后很差,5年生存率只有20%。骨髓间充质干细胞是来源于骨髓中的一种多能干细胞,具有多方向分化潜能,在临床上具有巨大的潜在应用价值。在近年国内外的相关研究中发现,骨髓间充质干细胞有可能参与肺损伤的修复,甚至能逆转肺纤维化的病理改变,但具体的作用机制仍不明确,需要进一步研究去阐明。

Idiopathic pulmonary fibrosis is a diffuse pulmonary fibrosis disease. At present, there are still no effective treatments for this disease, so the prognosis is poor and 5 years of survival rates was only 20%. Bone marrow mesenchymal stem cells （BMSCs）, derived from bone marrow, is a kind of multipotent stem cells, which have potential to differentiate into many lineages of cells. So, they are considered to have great latent values in clinic. In recent years, related studies had found that BMSCs might participate in the repair of the lung injury, even they can reverse the pathological progress in idiopathic pulmonary fibrosis. But the mechanism is still unclear and needs more research to elucidate.