摘要
促血管生成素(Ang)家族是调节血管生成的一类细胞因子,包括Ang-1、Ang-2、Ang-3和Ang-4等4个成员,Ang-1和Ang-2是其中最重要的成员。Tie-2是Ang家族的共同受体。Ang-1与Tie-2结合后激活下游信号通路,起到抑制内皮凋亡、促进内皮存活和迁移、维持血管完整性的作用;Ang-2则是Ang-1天然的抑制剂,其拮抗的效应与局部血管内皮生长因子(VEGF)的水平有关,VEGF存在时促进新生血管形成,VEGF缺乏时则有利于血管的消退。Ang参与生理和病理性的血管新生,与肿瘤和其他疾病有密切的关系,有广泛的应用前景。
The family of angiopoietin（Ang） plays an important role in the formation of the blood vascular system. It in- cludes four members of Ang-1, Ang-2, Ang-3 and Ang-4, which all bind to the receptor Tie-2. Ang-1 binds to Tie-2 and subsequently activates the downstream signaling pathway, leading to anti-apoptosis, survival and migration of endothe- lial cells. Ang-2 acts as a natural antagonist of Ang-1, playing a different role. In the presence of vascular endothelial growth factor（VEG10, Ang-2 leads to robust angiogenesis, while in the absence of VEGF, vessel regression results. An- giopoietin is involved in many diseases about angiogenesis such as tumor, so may have great prospects for the treatment of these diseases.
出处
《生物技术通讯》
CAS
2008年第6期925-927,共3页
Letters in Biotechnology
基金
国家自然科学基金面上项目(30672403)
