摘要
西尼罗病毒可引起鼠、人类及其他动物严重脑炎,近年来再度流行。基因研究分析表明近年来西尼罗病毒突变的速度逐渐加快,突变主要发生在基因编码区,这些突变可导致病毒蛋白E区、NS1区、NS2区及NS5区氨基酸序列的改变。西尼罗病毒感染主要发生于老龄及免疫缺陷动物或人群。西尼罗病毒的易感染性除与突变有重要关系外,与CCR5、OAS及CXCL10等受体及因子也有一定的关系。
West Nile virus （WNV） is a reemerging pathogen that causes fatal encephalitis in several species, including horses and humans. Analyzing of viral gene showed a steady increase in mutation of WNV in recent years. Most of the changes were in coding regions, causing amino acid substitutions in the E, NS1, NS2, and NSS. More severe disease pre- sentation of WNV generally occurs in older and immunodeficiency individuals. Susceptibility of WNV also had relationship with CCRS, OAS and CXCL10.
出处
《生物技术通讯》
CAS
2008年第6期928-930,共3页
Letters in Biotechnology
基金
全军医药卫生科研基金项目(06H056)
关键词
西尼罗病毒
突变
易感性
west Nile virus
mutation
susceptibility
