颈动脉狭窄患者血管内支架置入

Endovascular stent implantation in patients with carotid artery stenosis

血管内支架置入能使狭窄的血管得以重建,大脑得到充足的血液供应,有效防止脑缺血及脑梗死的发生,具有创伤小、安全性高和并发症少等特点,被认为是治疗颈动脉狭窄的新方法。但目前血管内支架置入后再狭窄仍影响介入治疗的长期疗效,支架置入损伤血管壁从而激活一系列的愈合过程是导致支架内再狭窄的主要原因,炎性反应在动脉粥样硬化的形成过程中可能起重要作用,药物洗脱支架通过局部输送针对支架置入后局部炎症的抗炎药物,以达到增加疗效、降低支架内再狭窄发生的目的。

Endovascular stent implantation can rebuild stenotic vessels, make sufficient blood supply in the brain, and effective prevent the occurrence of cerebral ischemia and cerebral infarction. This implantation is characterized by small wound, safety and few complications, and is considered a new method of treating carotid artery stenosis. However, restenosis following endovascular stent implantation still affects long-term outcomes of interventional therapy. Stent implantation injures vessel wall, activate series of healing process, which is the main reason of inducing restenosis of the stent. Inflammatory reaction plays an important role in atherosclerotic formation. Drug-eluting stent aims directly at anti-inflammatory agents against local inflammation following stent implantation via local transportation, which can increase outcomes and reduce the occurrence rate of restenosis in the stent.