ER、PR及C-erbB-2、p53在87例甲状腺癌中的表达及临床意义

Expression and clinical significance of ER,PR,C-erbB-2 and p53 in 87 cases of thyroid carcinoma

目的:检测甲状腺癌中ER、PR及C-erbB-2,p53的表达并探讨它们的临床意义。方法:应用免疫组化S-P法对87例甲状腺癌、20例腺瘤、20例瘤旁甲状腺组织进行ER、PR、C-erbB-2、p53的检测。结果:甲状腺癌中ER、PR的阳性表达率分别为64.4和63.2,均与细胞分化程度,组织学类型有关,但与年龄,性别无关。无淋巴结转移组的甲状腺癌ER、PR阳性率为75.4和70.5,显著高于有转移组的53.8和46.2(P<0.05)。C-erbB-2表达随癌组织分化程度增高而增高,p53表达随癌组织分化程度增高而减少,与C-erbB-2间呈负相关。在淋巴结转移组中C-erbB-2阳性率增高明显(P<0.01)。结论:ER,PR,C-erbB-2,p53可作为甲状腺癌分化及恶性程度的评价指标,并且能反映预后。

Objective ：To study the expression of the estrogen receptor（ ER）, progesterone receptor（ PR）, C - erbB - 2, p53 in thyroid carcinoma and their clinical significance. Methods： ER, PR, C - erbB - 2,1953 in 87 cases of thyroid carcinoma,20 cases of adinoma and 20 cases of adjacent normal tissues of thyroid＇tumor were exmined using the method of immunohistochemistry S - P. Results： The positive rates of ER and PR were 64.4% and 63.2% re- spectively in thyroid carcinomas, which correlated with differentiation and histologic types, however did not relate to age and sex. The positive rates of ER and PR in the nonmetastatic group were 75.4% and 70.5% ,significantly high- er than those of the metastastatic group which were 53.8% and 46.2% （P 〈 0.05）. The expression of C - erbB - 2 was increased with increasing of differentiation of the carcinoma. The expression of p53 was decreased with the in- creasing degree of differentiation. A significant inverse correlation was found beteen p53 and c - erbB - 2. The posi- tive rate of C -erbB -2 was obviously higher in the metastastatic cases （P 〈 0.01 ）. Conclusion： The expression of ER, PR, C - erbB - 2 and p53 were related to tumor differentiation and the degree of malignancy and may indicate a poor prognosis.