以树突状细胞疫苗为基础的肿瘤免疫治疗

Tumor immunotherapy based on tumor vaccines of dendritic cell

树突状细胞(DC)是目前发现的人体内功能最强的专职抗原呈递细(APC),近年来,以DC为基础的肿瘤免疫治疗越来越引起人们的重视,本文就DC生物学特征、DC瘤疫苗分类、抗瘤机制、抗原负载或转染方法、优缺点及其临床研究作一综述。

Dendritic cell （DC） is the most potent professional antigen presenting cells in human （APC）, recently, more and more people pay attention to tumor immunotherapy based on tumor vaccines of dendritic cell. In this review, the biology characteristics of the DC, classification of DC tumor vaccines, mechanisms of anti -tumor, methods of anti- gen laoding or transfection, and their use in clinical trials are elaborated.