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MCM2蛋白在肿瘤中的表达及意义 被引量：3

Expression of MCM2 protein in tumour and its prognostic significance
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摘要 微小染色体维持蛋白(MCM)是真核生物DNA复制的主要调控因子,在DNA复制的起始和延伸过程中有重要作用,是标志细胞增殖活性的新指标,MCM2是微小染色体维持蛋白家族中的一员,是研究肿瘤细胞生长及评估某些肿瘤预后的较好指标。 MCM（ minichromosome maintenance） protein is an essential regulator in the initiation and elongation steps of eukaryotie DNA replication. It is a new parameter of proliferating activity. MCM2 is a member of the minichromosome maintenance （MCM） protein family. It is valuable marker in studying proliferation and motility of neoplastic cells and assessing tumor progression and prognosis.
作者 张桂香 赵学东 赵卫平
机构地区 承德医学院附属医院妇科 承德市妇产院
出处 《现代肿瘤医学》 CAS 2008年第12期2210-2212,共3页 Journal of Modern Oncology
关键词 IMCM2蛋白 肿瘤 预 增殖标记物 DNA复制 MCM2 protein tumour prognosis marker of proliferation DNA replication
分类号 R730.23 [医药卫生—肿瘤]
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参考文献22

  • 1Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer[ J]. Nature ,2001,411 (6835) :342 - 348.
  • 2Lopez - Saez JF, de la Torte C, Pincheira J, et al. Cell proliferation and cancer[ J]. Histol Histopathol, 1998,13 (4) : 1197 - 1214.
  • 3Tye BK. MCM proteins in DNA replication [ J ]. Annu Rev Biochem, 1999 ;68:649 - 686.
  • 4Labib K, Tercero JA, Diftley JF. Uninterrupted MCM2 - 7 function required for DNA replication fork progression [ J ]. Science, 2000, 288(5471 ) :1643 - 1647.
  • 5Lei M, Tye BK. Initiating DNA synthesis : from recruiting to activating the MCM complex [ J]. J Cell Sci, 2001,114 ( 8 ) : 1447 - 1454.
  • 6Labib K, Kearsey SE, Diffley JF. MCM2 -7 proteins are essential components of prereplieative complexes that accumulate cooperatively in the nucleus during G1 - phase and are required to establish, but not maintain,the S-phase checkpoint [ J ]. Mol Biol Cell, 2001,12 ( 11 ) :3658 - 3667.
  • 7Todorov IT, Attaran A, Kearsey SE. BM28, a human member of the MCM2 - 3 - 5 family,is displaced from chromatin during DNA replication[J]. J Cell Biol, 1995,129 (6) : 1433 - 1445.
  • 8Alison MR, Hunt T, Forbes SJ. Minichromosome maintenance (MCM) proteins may be pre -cancer markers[ J]. Gut,2002,50 (3) :290 -291.
  • 9Going JJ, KeithWN, Neilson L, et al. Aberrant expression of minichromosome maintenance proteins2 and 5, and Ki - 67 in dysplastic squamous oesophageal epithelium and Barrett's mucosa [ J ]. Gut,2002,50 (3) :373 - 377.
  • 10Ramnath N,Hemandez FJ,Tan DF,et al. MCM2 is an independent predictor of survival in patients with non - small - cell lung cancer[ J ]. J Clin Oncol,2001,19 (22) :4259 - 4256.

同被引文献33

  • 1陈玮,赵涌.MCM5和Ki67在宫颈上皮内瘤变及宫颈癌组织中表达及意义[J].第三军医大学学报,2007,29(14):1436-1439. 被引量：11
  • 2Maiorano D, Lutzmann M, Mechali M. MCM proteins and DNA replication. Current Opinion in cell Biology, 2006, 18:130-136.
  • 3Lei M. The MCM complex: Its role in DNA replicaton and implications for cancer therapy. Curt Cancer Drug Targets, 2005, 5: 365-380.
  • 4Freeman A, Morris L S, Mills AD, et al. Miniehromosome maintenance proteins as biological markers of dysplasia and malignancy. Ctin Cancer Res, 1999, 5: 2121-2132.
  • 5Tan DF, Huberman J, Hyland A, et al. MCM2-a promising marker for premalig-nant lesions Of the lung: a cohort study. BMC Cancer, 2001, 1:6.
  • 6Yang J, Rarnnath N, Moysich KB, et al. Prognostic significance of MCM2, Ki-67 and gelsolin in non-small cell lung cancer. BMC Cancer, 2006, 6:203-213.
  • 7Ramnath N, Hernandez FJ, Tan DF, et al. MCM2 is an independent predictor of survival in patients with non-small-cell lung cancer. J Clin Oncol, 2001, 19: 4259-4266.
  • 8Alison MR, Hunt T, Forbes SJ. Minichromosome maintenance (MCM) proteins may be pre -cancer markers [J]. Gut, 2002, 50 (3) : 290.
  • 9Dudderidge TJ, Stoeber K, Loddo M, et al. MCM2, Geminin, and Ki67 define proliferative state and are prognostic markers in renal cell carcinoma [J]. Clin Cancer Res, 2005, 11 (7) : 2510.
  • 10Kato H, Miyazaki T, Fukai Y, et al. A new proliferation marker, minichromosome maintenance protein 2, is associated with tumor aggressiveness in esophageal squamous cell carcinoma [J] . J Surg Oncol, 2003, 84 (1): 24.

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现代肿瘤医学
2008年 第12期

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