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UCP2与细胞凋亡 被引量：6

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摘要 解偶联蛋白2(uncoupling protein2,UCP2)是线粒体内膜上的一种蛋白,基因定位于11号染色体上(11q13)上,基因全长8.4kb,有8个外显子。它对线粒体的质子泵(protonpump)有调节的作用。它的调节能够从多种途径减缓,甚至抑制细胞的凋亡(apoptosis)和线粒体的损伤。其原因是UCP2能够减少△Ψm(线粒体跨膜电位)的变化,减少了线粒体Ca2+的沉积和活性氧类(reactive oxygen species,ROS)的产生,减少线粒体通透性转换孔(permeability transition pore,PTP)的开放和细胞色素C的释放。此外,UCP2还能抑制某些因素对NF-κB通路系统的激活,从而阻止细胞的凋亡。
作者 施宏华 孙雅文 李稻
机构地区 上海交通大学医学院病理生理学教研室
出处 《现代肿瘤医学》 CAS 2008年第12期2227-2229,共3页 Journal of Modern Oncology
关键词 细胞凋亡 UCP2 LPC ROS △Ψm
分类号 R730.23 [医药卫生—肿瘤]
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参考文献19

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同被引文献43

  • 1陈玉华,武革.解偶联蛋白与甲状腺激素对能量代谢调节的研究现状[J].广东医学院学报,2006,24(2):197-199. 被引量：6
  • 2管晓翔,陈龙邦.雄激素非依赖性前列腺癌的治疗进展[J].中华男科学杂志,2006,12(11):1021-1025. 被引量：7
  • 3苗艳君,石建华,项平.解偶联蛋白与能量代谢[J].实用全科医学,2007,5(5):452-453. 被引量：5
  • 4Patel PH,Chaganti RS,Motzer RJ. Targeted therapy for metastatic renal cell carcinoma [J]. Br J Cancer,2006,94 (5):614-619.
  • 5Blenmer I, Oosterwijk E, De Mulder P, et al. Immunother- apy for renal cell carcinoma [J]. Eur Urol,2003,44(1 ): 65-75.
  • 6Escudier B,Eisen T,Stadler WM,et al. Sorafenib in ad- vanced clear-cell renal cell carcinoma[J]. N Engl J Med, 2007,356(2):125-134.
  • 7Eisen T,Oudard S,Szczylik C,et al. Sorafenib for older patients with renal cell carcinoma:subset analysis from a randomized trial [J]. J Natl Cancer Inst,2008,100(20) : 1454-1463.
  • 8Maximo V, Lima J, Soares P, et al. Mitochondria and can- cer[ J ]. Virchows Archiv, 2009,454 (5) :481-495.
  • 9Kitano H. Cancer as a robust system:implications for an- ticaneer therapy[J]. Nat Rev Cancer,2004(4):227-235.
  • 10Hong HY,Kim BC. Mixed lineage kinase 3 connects re- active oxygen species to c-Jun NH2-terminal kinase in- duced mitochondrial apoptosis in genipin- reated PC3 human prostate cancer cells[J]. Biochem Biophy Res Communi, 2007 (362) : 307-312.

引证文献6

二级引证文献12

现代肿瘤医学
2008年 第12期

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