老年冠心病抑郁患者白细胞介素17和C反应蛋白的变化

Changes of Interleukin-17 and C-Reative Protein in Aging Patients of Coronary Artery Disease with Depression

目的探讨老年冠心病抑郁患者血浆白细胞介素17及C反应蛋白浓度的变化。方法选择38例老年冠心病抑郁患者为研究对象,同时以30例老年冠心病非抑郁患者为对照组,采用夹心酶联免疫吸附法检测血浆白细胞介素17及C反应蛋白浓度。结果老年冠心病抑郁患者血浆白细胞介素17和C反应蛋白浓度明显高于对照组(341.72±134.28ng/L比214.33±82.51ng/L和4.93±2.15μg/L比1.93±1.25μg/L,P<0.01),老年冠心病抑郁组中急性冠状动脉综合征患者血浆白细胞介素17和C反应蛋白浓度明显高于稳定型心绞痛患者(382.17±165.35ng/L比305.47±119.75ng/L和5.96±2.31μg/L比4.12±2.44μg/L,P<0.01)。老年冠心病轻-中度抑郁患者及重度抑郁患者血浆白细胞介素17浓度明显高于对照组(310.27±138.25ng/L和395.42±158.75ng/L比214.33±82.51ng/L,P<0.05),且重度抑郁组高于轻-中度抑郁组(P<0.05)。老年冠心病轻-中度抑郁患者及重度抑郁患者血浆C反应蛋白浓度明显高于对照组(4.35±2.01μg/L和5.84±1.87μg/L比1.93±1.25μg/L,P<0.05),重度抑郁患者血浆C反应蛋白水平明显高于轻-中度抑郁患者(P<0.05)。老年冠心病抑郁患者血浆C反应蛋白浓度与血浆白细胞介素17浓度呈显著正相关(r=0.802,P<0.05),血浆白细胞介素17和C反应蛋白浓度与抑郁评分呈正相关(r分别为0.674和0.421,P<0.05)。结论白细胞介素17和C反应蛋白在老年冠心病抑郁患者的发病机理中可能起重要的作用。

Aim To study the levels of interleukin-17 （IL-17） and C-reactive protein （CRP） in plasma of aging coronary heart disease patients with depression. Methods The concentrations of IL-17 and CRP in plasma were examined by using enzym-linked immunosorbent assay in 68 aging coronary heart disease patients which were divided into two groups： depression group （n=38） and un-depression group （n=30）. Results Concentrations of IL-17 and CRP were significantly higher in aging depression patients with coronary heart disease than those of the control group （341.72±134.28 ng/L vs 214.33±82.51 ng/L and 4.93±2.15 μg/L vs 1.93±1.25 μg/L, P〈0.01）. Levels of IL-17 and CRP in acute coronary syndrom were higher than that in stable angina patients （382.17±165.35 ng/L vs 305.47±119.75 ng/L and 5.96±2.31 μg/L vs 4.12±2.44 μg/L, P〈0.01）. Concentration of IL-17 in aging coronary heart disease patients with minor to moderate depression and major depression were significantly higher than those of non-depression patients （310.27±138.25 ng/L and 395.42±158.75 ng/L vs 214.33±82.51 ng/L, P〈0.05）, the concentrations of IL-17 major depression in aging coronary heart disease depression were higher than that of minor to moderate depression in aging patients with depression. The plasma levels of CRP in aging coronary heart disease patients with minor to moderate depression and major depression were increased as compared with the non-depression patients （4.35±2.01 ng/L and 5.84±1.87 ng/L vs 1.93±1.25 ng/L,P〈0.05）. The levels of major depression were increased as compared with minor to moderate depression patients. The levels of CRP were positively related with IL-17 in aging coronary heart disease patients with depression （r=0.802, P〈0.05）. The concentration of IL-17 and CRP were positively associated with the scores of depression （r=0.674, P〈0.0, r=0.421,P〈0.05）. Conclusion Interleukin-17 and C-reactive protein play a role in the mechanism of aging coronary heart disease with depression.