冠心病合并焦虑障碍患者血浆NPY、NE、DA、5-HT的变化及意义

The Content Changes of Plasmic NPY,NE,DA,and 5-HT and Their Significance in Patients with Coronary Heart Disease Accompanied by Anxiety

目的:探讨冠心病(CHD)合并焦虑障碍患者血浆神经肽Y(NPY)、去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)水平的变化及其临床意义。方法:71例经选择性冠状动脉造影确诊为CHD的住院病人,通过Zung焦虑自评量表(SAS)问卷调查分为焦虑障碍组和对照组;统计年住院次数及年住院天数,运用放射免疫法和免疫荧光法检测患者血浆NPY和NE、DA、5-HT含量。结果:与对照组比较,合并焦虑障碍的CHD患者年住院次数及年住院天数均明显增多,血浆NPY、NE、DA、5-HT水平也显著增高,且均具有统计学差异(P<0.05)。结论:合并焦虑障碍的CHD患者年住院次数及天数明显增加,血NPY、NE、DA、5-HT的异常增加可能参与了CHD患者合并焦虑障碍的发生发展过程。

Objective： To explore the content changes of plasmic neuropeptide Y （NPY）, norepi- nephrine （NE）, 5 - hydroxytryptamine （ 5-HT）, dopamine （ DA ） and their clinical significance in patients with coronary heart disease with CHD, diagnosed with selective （CHD） accompanied by anxiety. coronary arteriougraphy method, Methods： Seventy-one patients were divided into anxiety group and control group by Self-Rating Anxiety Scale （SAS）. The times and days of hospitalization of these patients were recorded. Levels of plasmic NPY, NE, DA and 5-HT were detected by using radioimmu- noassay and immumofluorescence methods in all of the patients. Results： （1） The numbers of time and day in hospital of patients in group A were bigger than those of patients in group B （ P 〈 0.05 ） （2） The levels of plasmic NPY, DA, NE, and 5-HT of patients in group A were significantly higher than those of patients in group B （P 〈 0.05）. Conclusions： （1） The increase of hospitalization times and days of CHD patients accompanied by anxiety should cause the attention of clinical doctors specially doctors of cardiovascular diseases ; （2） The unusual increase of plasmic NPY, DA, NE, and 5-HT indicates that they might be involved in the pathophysiologic process of anxiety accompanied CHD.