七羟基-β-二氢沉香呋喃醚类衍生物的合成及其杀虫活性

Synthesis and Insecticidal Activity of Hepthydroxy-β-dihydroagarofuran Ether Derivatives

以苦皮藤（Celastrus angulatus Max.）提取物水解产物中的1β，2β，4α，6α，8β，9α，12-七羟基-β-二氢沉香呋喃为起始原料，经丙酮保护，甲磺酰化，四氢铝锂还原，脱丙酮保护4步反应得到了1β，2β，4α，6α，8α，9α，12-七羟基-β-二氢沉香呋喃，并以此设计合成了11个新的二氢沉香呋喃醚类衍生物（5.1-5.11），其结构经核磁共振谱、质谱等方法鉴定。初步的杀虫活性测定结果表明：化合物（5.1-5.11）对3龄粘虫（My-thimna separata）幼虫均具有一定的胃毒和拒食活性，其中化合物5.1在1%浓度下的拒食活性为95.2%；化合物5.1，5.8对白纹伊蚊（Aedes albopictus）具有显著的活性，其中5.1在150 mg/L的浓度下对白纹伊蚊的死亡率为94.6%。

1β,2β,4α,6α,8β,9α,12-hepthydroxy-13-dihydroagarofuran was modified to 1β,2β,4α,6α,8β,9α,12-hepthydroxy-β-dihydroagarofuran and eleven new dihydroagarofuran ether derivatives were synthesized based on 1β,2β,4α,6α,8β,9α,12-hepthydroxy-β-dihydroagarofuran. And The structures of the compounds were elucidated mainly based on NMR and Ms spectral data. Bioassay results indicated that they exhibited some degree stomach poison and antifeedant activity against the third instar larvae of Mythimna separata at the concentration of 20 mg/mL, some of the compounds exhibited significant activity against the third instar larvae of Aedes albopictus at the concentration of 150 mg/Lo