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人恶性肿瘤中NKG2D受体配体的表达在免疫调节中的作用 被引量：4

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摘要 NKG2D(natural killer group 2 member D)受体及其配体是目前研究比较多的免疫学分子。NKG2D受体在与其配体结合后可以激活NK细胞和T细胞,杀伤有NKG2D受体配体表达的肿瘤细胞,因此NKG2D受体及其配体在肿瘤的免疫调节过程中有着重要作用。人类NKG2D受体的配体包括:主要组织相容性复合体I类相关蛋白(major histocompatibility complex class I-related protein,MIC)A和B以及UL-16结合蛋白(UL16 binding protein,ULBP)。这些配体广泛表达于各种肿瘤表面,通过各种不同的机制对肿瘤免疫进行调节。
作者 李奎 温宏武 廖秦平
机构地区 北京大学第一医院妇产科
出处 《肿瘤》 CAS CSCD 北大核心 2008年第11期1015-1018,共4页 Tumor
关键词 肿瘤 肿瘤免疫 NKG2D受体 配体
分类号 R730.3 [医药卫生—肿瘤]
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参考文献43

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同被引文献71

  • 1HongZhang Shao-HuaChen You-MingLi.Epidemiological investigation of esophageal carcinoma[J].World Journal of Gastroenterology,2004,10(12):1834-1835. 被引量：22
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  • 3郑为东.活化性受体NKG2D及其配体的研究进展[J].国际免疫学杂志,2007,30(4):262-265. 被引量：1
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肿瘤
2008年 第11期

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