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靶向细胞周期检验点的肿瘤治疗 被引量：1

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作者 潘宇 邵荣光
机构地区 中国医学科学院中国协和医科大学医药生物技术研究所
出处 《解放军医学杂志》 CAS CSCD 北大核心 2008年第11期1387-1388,共2页 Medical Journal of Chinese People's Liberation Army
基金 国家重点基础研究发展计划(973计划)项目(2002CB513108)
关键词 细胞周期检验 DNA损伤 DNA修复 肿瘤治疗方案
分类号 R730.5 [医药卫生—肿瘤]
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参考文献19

  • 1邵荣光.以细胞周期调控分子为靶点的肿瘤治疗[J].中国肿瘤,2005,14(11):706-708. 被引量：11
  • 2Niida H, Nakanishi M. DNA damage checkpoints in mammalas. Mutagenesis, 2006, 21(1):3.
  • 3Helleday T, Petermannl T, Lundinl C, et al. DNA repair pathways as targets for cancer therapy. Nat Rev Cancer, 2008, 8(3):193.
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  • 6Di Micco R, Fumagalli M, Cicalese A,et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature, 2006, 444(7119):638.
  • 7DiTullio RA Jr, Mochan TA, Venere M, et al. 53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer. Nat Cell Biol, 2002, 4(12):998.
  • 8Halazonetis TD, Gorgoulis VG, Bartek J. An onoongen-induced DNA damage model for cancer development. Science, 2008, 319(5868):1352.
  • 9Gorgoulis VG, Vassiliou LV, Karakaidos P, et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature, 2005, 434(7035) :907.
  • 10Bartkova J, Horejsi Z, Koed K, et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature, 2005, 434(7035) :864.

二级参考文献3

共引文献10

同被引文献17

  • 1Hurley LH. DNA and its associated processes as targets for cancer therapy[J]. Nat Rev Cancer, 2002, 2(3): 188-200.
  • 2Kohn KW, Jackman J, O'Connor PM. Cell cycle control and cancer chemotherapy[J]. J Cell Biochem, 1994, 54(4): 440-452.
  • 3Hartwell LH, Kastan MB. Cell cycle control and cancer[J]. Science, 1994, 266(5192): 1821-1828.
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  • 5Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective[J]. Nature, 2000, 408(6811): 433-439.
  • 6Pan Y, Ren KH, He HW, et al. Knockdown of Chkl sensitizes human colon carcinoma HCTll6 ceils in a p53-dependent manner to hdamycin through abrogation of a G2/M checkpoint and induction of apoptosis[J]. Cancer Biol Ther, 2009, 8(16): 1559-1566.
  • 7Helleday T, Petermann E, Lundin C, et al. DNA repair pathways as targets for cancer therapy[J]. Nat Rev Cancer, 2008, 8(3): 193-204.
  • 8Ashwell S, Zabludoff S. DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy[J]. Clin Cancer Res, 2008, 14(13): 4032-4037.
  • 9Mukhopadhyay UK, Senderowicz AM, Ferbeyre G. RNA silencing of checkpoint regulators sensitizes p53-defective prostate cancer cells to chemotherapy while sparing normal cells[J]. Cancer Res, 2005, 65(7): 2872-2881.
  • 10Flatten K, Dai NT, Vroman BT, et al. The role of checkpoint kinase 1 in sensitivity to topoisomerase I poisons[J]. J Biol Chem, 2005, 280(14): 14349-14355.

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解放军医学杂志
2008年 第11期

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