OK-432病变内注射后舌下腺囊肿囊液中IL-1α、TNF-β的变化及意义

The variation and significance of IL-1α、TNF-β in the cyst fluid of ranula before and after OK-432 intrale-sional injection

目的:检测OK-432注射前后舌下腺囊肿囊液中IL-1α和TNF-β的含量变化,探讨OK-432治疗的机理。方法:11例舌下腺囊肿患者(单纯型5例,下陷型6例)接受病变内注射OK-432治疗,观察临床疗效,治疗前后抽取囊液分析IL-1α和TNF-β的含量。结果:11例中7例经过一次硬化治疗后囊肿完全消失,2例经过二次治疗后囊肿完全消失,治愈率达82%。患者治疗前后囊液中IL-1α的含量分别为21pg/ml和765pg/ml,TNF-β的含量分别为39pg/ml和1146pg/ml,有显著性差异。结论:病变内注射OK-432治疗舌下腺囊肿效果好,其机理可能与细胞因子的分泌有关。

Objective： To measure the concentration of IL-1α and TNF-β in the cyst fluid of ranulas before and after OK-432 intralesional injection, and explore the possible mechanism of OK-432 sclerotherapy. Method： 11 patients with ranula （simple ranula 5 cases, plunging raula 6 cases）were treated by OK-432 intralesional injection, the IL-1αand TNF-β of the cystic fluid were detected by ELISA before and after treatment.Result： Of 11 ranulas, 7 was cured by one injection of OK-432,2 was cured by two injections of OK-432,the cured rate is 82% ：the concentration of IL-1α before and after treatment was 21 pg / mland 765 pg / ml respectively, the concentration of TNF-βbefore and after treatment was 39 pg / ml and 1146 pg / ml respectively, the difference was significant （p 〈 0.01）. Conclusion： OK-432 intralesional injection is relatively safe method in treatment of ranula, the possible mechanism maybe related to the IL-1α and TNF-β.