PD-1/PD-Ls对自身免疫病及慢性感染的影响及对OLP研究的启示
被引量：1
摘要
PD-1及其配体属于B7:CD28免疫球蛋白超家族,是最近发现的向T细胞激活传导抑制信号的共刺激分子,在诱导、维持外周耐受,阻止自身免疫性疾病发生发展中发挥重要作用。同时,细菌、病毒、寄生虫等病原微生物及肿瘤细胞亦可利用这一负性信号传导途径引起T细胞功能障碍,从而导致机体慢性持续性感染及肿瘤逃逸。PD-1及其配体作为关键的共抑制分子,显示了其在免疫治疗调控中作为潜在治疗靶点的临床应用前景。
出处
《临床口腔医学杂志》
2008年第11期696-698,共3页
Journal of Clinical Stomatology
参考文献19
-
1ho T, Ueno T, Clarkson MR, et al. Analysis of the role of negative T cell costimulatory pathways in CD4 and CD8^+ T cell-mediated alloimmune responses in vivo [J]. J Immunol, 2005, 174 (11) : 6648-56.
-
2Zhong X,Tumang JR, Gao W, et al. PD-L2 expression extends beyond dendritic cells / macrophages to B1 cells enriched for V (H) 11 /V (H)12 and phosphatidylcholine binding [J]. Eur J Immunol, 2007, 37 (9) : 2405-10.
-
3Muhlbauer M, Fleck M, Schatz C, et al. PD-L1 is induced in hepatocytes by viral infection andby inter-feron-α and -γ and mediates T cell apoptosis [J]. J Hepatol, 2006, 45 (4-) : 520-528.
-
4Sehreiner B, Mitsdoerffer M, Kieseier BC,et al. Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologus T cell activation: relevancen for the immune modulatory effect in multiple sclerosis [J]. J Neuroimmunol, 2004, 155 (1-2) : 172-182.
-
5Ansari MJ,Salama AD, Chitnis T,et al. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice [J]. J Exp Med, 2003, 198 (1) : 63-69.
-
6Zhu B,Guleria I, Khosroshahi A,et al. Differential role of programmed death-ligand2 in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis [J]. J Immunol, 2006,176 (6) : 3480-9.
-
7Butte MJ,Keir ME, Phamduy TB,et al. Programmed death-1 ligand 1 interacts specially with the BT-1 costimulatory molecule to inhibit T cell responses [J]. Immunity, 2007,27 (1) : 111-122.
-
8Liang SC, Latchman YE, Buhlmann JE, et al. Regulation of PD-1, PD-L1,and PD-L2 expression during normal and autoimmune responses [J]. Eur J Immunol, 2003,33 ( 11 ) : 2706-16.
-
9Wang CJ, Chou FC,Chu CH,et al. Protective role of programmed death 1 ligand 1 in nonobese diabetic mice: the paradox in transgenic models[J]. Diabetes, 2008, 16.
-
10Hirata S, Senju S, Matsuyoshi H, et al. Prevention of EAE by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein along with TRAIL or pro~ammed death- 1 ligand [J]. J Immunol, 2005, 174 (4) : 1888-97.
同被引文献19
-
1唐裕杰,邓安梅,仲人前.PD-1在慢性病毒感染性疾病中的研究进展[J].现代免疫学,2008,28(4):335-338. 被引量：1
-
2GOLDEN-MASON L,KLARQUIST J,WAHED A S,et al.Programmed death-1expression is increased on im-munocyte in chronic hepatitis C virus and predicts failure to antiviral therapy:race-dependent differences. J Immunol . 2008
-
3MARIANNE M,MARTINIC,MATTHIAS G,et al.Novel strategies to eliminate persistent viral infections. Journal of Autoimmune Diseases . 2008
-
4SMHENSON,RMACAULAY,SKIANI-ALIKHAN,et al.The use of the inhibitory receptors for modulating the im-mune responses. J Immunology . 2008
-
5ITO T,UENO T,CLARKSON MR,et al.Anslysis of the of negative T cell costimulatory pathways in CD4+and CD8+T cell-mediated alloimmune responses in vivo. J Immunal . 2005
-
6NAKAE S,SUTO H,LIKARA M,et al.Mast cell en-hance T cell activation:important of mast cell costimula-tory molecules and secreted TNF. J Immunal . 2006
-
7ALEXANDER EVANS,ANTONIORIVA,HELENCOO-KSLRY,et al.Programmed death1expression during antiviral treatment of hepatitis b:Impact of hepatitis b e-antigen seroconversion. Journal of Hepatology . 2008
-
8Barber,DL,Wherry,EJ,Masopust,D.Restoring function in exhausted CD8 T cells during chronic viral infection. Nature . 2006
-
9Barber,DL,Wherry,EJ,Masopust,D.Restoring function in exhausted CD8 T cells during chronic viral infection. Nature . 2006
-
10Boni C,Fisicaro P,Valdatta C,et al.Characterization of hepatitis B virus(HBV)-specific T-cell dysfunction in chronic HBVinfection. Journal of Virology . 2007
-
1石越众,余百川.川崎病系统损害的临床分析[J].心肺血管病杂志,1993,12(1):11-13.
-
2张文怡,唐国瑶.MicroRNA-146在自身免疫病中的研究进展及其对OLP研究的启示[J].临床口腔医学杂志,2010,26(5):309-311. 被引量：2
-
3郭起,刘宏鹏,王慧茹,刘贵锁.类风湿关节炎致颞下颌关节强直六例分析[J].中华风湿病学杂志,2002,6(6):458-459.
-
4邹兆菊,王松灵.成人复发性腮腺炎[J].中华口腔医学杂志,1993,28(5):258-260. 被引量：2
-
5吕亚林,Hai Zhang.2012年第三届欧洲骨结合学会共识研讨会报告(种植体修复重建部分)及对我国种植修复的启示[J].中华临床医师杂志（电子版）,2013,7(10):164-165. 被引量：1
-
6罗伟.宝宝磨牙，未必肚里有虫[J].中国家庭医生,2016,0(15):25-25.
-
7傅超.磨牙不只是寄生虫在作祟[J].医药与保健,2002,10(9):44-44.
-
8黄静文.慢性牙周炎患者外周血T淋巴细胞中PD-1和PD-1L的表达量及其与炎症反应程度的相关性[J].海南医学院学报,2017,23(2):262-265. 被引量：16
-
9李青,汪昌宁,宋亚玲.NALP3炎性体与相关疾病的研究进展[J].牙体牙髓牙周病学杂志,2011,21(6):355-359. 被引量：6
-
10陶大伟.防治牙龈炎降低心脏病的风险[J].心血管病防治知识,2009,0(1):46-46.
