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Immunologic pathogenesis of multiple sclerosis 被引量：6

多发性硬化的免疫学发病机制(英文)
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摘要 Multiple sclerosis （MS） is an autoimmune disease. The etiology and pathogenesis of MS remain unclear. At present, there are substantial evidences to support the hypothesis that genetics plays a crucial role. The people who have genetic predisposing genes easily develop immune-mediated disorder, probably in conjunction with environmental factors. The aim of this review is to describe recent observations regarding the immunologic pathogenesis of MS. 多发性硬化是一种自身免疫性疾病,其发病机制至今还未阐明,目前认为可能是一些携有先天遗传易感基因的个体有易发生免疫调节功能紊乱的趋势,在后天环境中外因的作用下,诱发对中枢髓鞘成分的异常自身免疫应答而致病。本文综述了近年来的相关文献和科研成果,旨在探讨多发性硬化的免疫学发病机制。
作者 郭敏芳 纪宁 马存根
机构地区 山西大同大学脑科学研究所
出处 《Neuroscience Bulletin》 SCIE CAS CSCD 2008年第6期381-386,共6页 神经科学通报（英文版）
基金 supported by the Natural Science Foundation of Shanxi Province,China(No.2008011082-1).
关键词 multiple sclerosis IMMUNOLOGY PATHOGENESIS 多发性硬化 免疫学 发病机制 自身免疫性疾病
分类号 R744.51 [医药卫生—神经病学与精神病学] R392 [医药卫生—免疫学]
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参考文献45

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同被引文献85

  • 1戚晓昆.中枢神经系统炎性脱髓鞘病的研究进展(述评)[J].中国神经免疫学和神经病学杂志,2003,10(3):141-143. 被引量：17
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  • 8Gao ZL,Zhou N,Chen J,Zhang CH.Clinical analysis of 130 patients with multiple sclerosis[].Acta Universitatis Medicinalis Anhui.1995
  • 9Li HP,Zhan QM,Wang YZ,Sun B.MRI, EP and clinical study in multiple sclerosis[].Med J Chin Peoples Liberation Army.1995
  • 10Chen KM,Zhang X,Xia JH.Clinical characteristic of 158 pa- tients with multiple sclerosis[].Chin J Pract Nerv Dis.2008

引证文献6

二级引证文献10

Neuroscience Bulletin
2008年 第6期

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