可切除直肠癌术前放化疗研究进展

Advance in Preoperative Radiochemotherapy for Resectable Rectal Cancer

术前放疗在直肠癌综合治疗中的目标是提高局部控制率,增加保肛的几率,提高生存率及生活质量。随机临床研究已证实术前放疗联合化疗的综合治疗,较单纯手术或术前联合单纯放疗可显著提高肿瘤的局部控制率。更多有效的药物及新配伍方案的引入,对直肠癌患者采取个体化的术前放化疗,将使直肠癌的治疗效果得到进一步提高。本文综述了直肠癌术前放化疗的现状和进展。

The aim of preoperative radiotherapy for rectal cancer is to improve the local control rate, increase the possibility for sphincter preservation, and improve the survival and the quality of life. Randomized clinical trials have shown that combining radical surgery with preoperative radiochemotherapy is more effective in improving the local control rate as compared with radical surgery or preoperative radiotherapy alone. With introduction of more effective novel chemotherapeutic agents and schemes of their combination, multimodal treatment with preoperative radiochemotherapy will be applied individually to treat selected patients, which is expected to further enhance the therapeutic effect of rectal cancer. This article reviewed the current status and development of preoperative radiochemotherapy for rectal cancer.