摘要
腺苷对于创伤性脑损伤（traumatic brain injury，TBI）后能量代谢的影响国内未见报道。Bentzer等对液压致伤大鼠伤侧和对侧脑组织伤后24—48h能量代谢变化进行研究，发现致伤对侧脑组织在伤后24～48h无明显能量代谢变化。但是临床上经常发现创伤对侧脑组织有对冲伤，理论上此位置应该存在能量代谢的改变，似与上述实验结果不符，所以有必要对受伤对侧脑组织的能量代谢变化进行研究。笔者使用微透析技术，通过观察致伤大鼠伤后5h内致伤对侧海马区脑组织细胞外液（ECF）中葡萄糖（Glu）、乳酸（Lac）、丙酮酸（Pyru）、甘油（Gly）的变化以及外源性腺苷、2-氯腺苷和腺苷激酶抑制剂（Abt-702）对其的影响，探讨腺苷对TBI后能量代谢的作用。
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2008年第12期1007-1009,共3页
Chinese Journal of Trauma
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