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FXR:一种多功能的核受体 被引量：1

FXR,A Multifunctional Nuclear Receptor
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摘要 FXR作为一种胆汁酸激活的核受体,通过调控一系列基因的表达,在胆汁酸代谢、脂代谢、糖代谢、肝脏保护、肠道细菌的生长和动脉粥样硬化的发生发展中发挥着重要的作用。因此,FXR有望作为治疗胆汁淤积、高甘油三酯血症、2型糖尿病等的药物靶点。 The Farnesoid X Receptor （FXR）, activated by bile acid, acts as a multifunctional nuclear receptor and plays vital roles in metabolism of bile acid, lipid and glucose, protection of liver （hepatoprotection）, control of intestinal bacterial growth, and pathogenesis of atherosclerosis. Hence, the involvement of FXR in metabolic signaling makes it particularly attractive target for therapeutic intervention of human cholestasis, hypertriglyceridemia and type-2 diabetes.
作者 王强 张艳 江渝
机构地区 第三军医大学学员旅五队 第三军医大学生物化学与分子生物学教研室
出处 《医学分子生物学杂志》 CAS CSCD 2008年第6期529-534,共6页 Journal of Medical Molecular Biology
基金 重庆市自然科学基金(No.CSTC2007BB5050) 第三军医大学留学回国人员启动基金(No.06HG010)~~
关键词 FXR 胆汁酸代谢 脂质代谢 代谢性疾病 FXR bile acid metabolism lipid metabolism metabolic disorders
分类号 Q591.5 [生物学—生物化学]
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参考文献40

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同被引文献44

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  • 8NAKAMURA M, NISHIDA N, KAWASHIMA M, et al. Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrho- sis in the Japanese population J]. Am J Hum Genet, 2012,91 (4) :721-728.
  • 9KARLSEN T H, FRANKE A, MELUM E, et al. Genome- wide association analysis in primary sclerosing cholangitis [ J ] Gastroenterology, 2010,138 (3) : 1102-1111.susceptibility loci[ J ]. Nat Genet, 2011,43 (1) :17-19.
  • 10MELUM E, FRANKE A, SCHRAMM C, et al. Genome- wide association analysis in primary sclerosing cholangitis identifies two non-HLA.

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医学分子生物学杂志
2008年 第6期

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