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肥胖与—相胰岛素分泌

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摘要 胰岛素抵抗（IR）和胰岛细胞分泌受损是2型糖尿病的两大发病机制，IR早在糖耐量受损阶段即已存在。然而只有胰岛素敏感性降低，没有胰岛β细胞功能的下降是不会发生糖尿病的。英国前瞻性糖尿病研究（UKPDS）提示在糖尿病诊断前的10-15年，胰岛β细胞功能已开始逐渐下降，也有报道认为胰岛β细胞功能异常甚至先于IR出现。
作者 罗昌正 严孙杰
机构地区 福建医科大学附属第一医院内分泌科
出处 《中国医师进修杂志（内科版）》 2008年第12期62-64,共3页 Chinese Journal of Postgraduates of Medicine
基金 福建省教育厅科技项目（JA05263）
关键词 胰岛素分泌 胰岛Β细胞功能 2型糖尿病 β细胞功能异常 肥胖 胰岛素抵抗 糖耐量受损 敏感性降低
分类号 R587.1 [医药卫生—内分泌] R587.102 [医药卫生—内分泌]
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参考文献20

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二级参考文献28

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中国医师进修杂志（内科版）
2008年 第12期

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