摘要
目的探讨帕罗西汀治疗骨科慢性疼痛性疾病伴发抑郁的疗效和安全性。方法将80例骨科慢性疼痛性疾病伴发抑郁的患者随机分为治疗组和对照组,每组40例。治疗组给予帕罗西汀20mg/d,对照组给予安慰剂1片/d。分别于治疗第4周末评价临床总体疗效,并用汉密尔顿抑郁量表(HAMD)及不良反应症状量表(TESS)定量测评两组患者治疗前后的抑郁变化情况及用药后的不良反应。结果治疗组总有效率(痊愈率+显著有效率+有效率)和显效率(痊愈率+显著有效率)分别达92.31%和64.10%,明显优于对照组。帕罗西汀主要的不良反应为短暂的轻至中度的恶心、食欲下降、头晕、困倦等。结论帕罗西汀用于治疗骨科慢性疼痛性疾病伴发抑郁疗效肯定,不良反应少,值得进一步研究和推广。
Objective To explore the efficiency and safety of paroxetine in treatment of the patient with chronic pain. Methods 80 patients with the chronic pain were randomly divided into study group(40 cases) and control group (40 cases) . the study group with paroxetine 20 mg every day and control group with Placebo one piece every day. Mter the fourth weekend, the clinical efficacy and side-effects were assessed with HAMD and TESS. Results The total effective rate of the study group was 92. 31%, good and the ideal improvent rate was 64. 10%. The rate is bigger than that in control group. The adverse reactions of paroxetine was mild, for example: nausea, lose appetite, dizziness, drowsiness, et al. Conclusion Paroxetine was effective in treatment of the patient with chronic pain and depression and the side effects were mild. It is worthwhile for study ulteriorly and generalize the clinical use.
出处
《中国实用医药》
2008年第31期11-12,共2页
China Practical Medicine