AFP、CA199、β_2-MG联合检测在肝癌诊治中的应用

AFP,CA199,β_2-MG union examination diagnose at the livercancer the application

目的探讨多种肿瘤标志物联合检测对原发性肝癌的诊断价值。方法用化学发光法检测50例原发性肝癌(PHC)患者、40例肝硬化患者及100例健康体检者血清肿瘤标志物AFP、CA199、β2-MG的水平。结果原发性肝癌各项指标与正常相比较三项标志物差异均有统计学意义(P<0.01)。原发性肝癌组单项AFP、CA199、β2-MG阳性率分别为68%、58%、76%,3项联合检测阳性率为84%。结论AFP、CA199、β2-MG三项肿瘤标志物联合检测可提高肝癌的阳性符合率,对诊断及鉴别诊断肝癌具有重要意义。

Objective To discuss the many kinds of tumors sign union examination to theprimary liver cancer diagnosis value. Methods Using chemiluminescence detection 50 cases of primary hepatocellular carcinoma （PHC） patients, 40 cases of patients with cirrhosis and 100 cases of physical examination serum tumor markers AFP, CA199, β2- microglobulin levels. Results Primary liver cancer each target and normal compares three item of designated objects to have the significance difference （ P 〈 0. 01 ）. Primary liver cancer group single item AFP, CA199, β2-MG the masculine gender rate respectively is 68% , 58% , 76% ,3 union examination masculine gender rate is 84%. Conclusion AFP, CA199, 132-MG three item of tumor designated object union examination may enhance liver cancer the masculine coincidence rate, to diagnoses and the distinction diagnosis liver cancer has the vital significance.