高血压患者血浆D-二聚体的检测及临床意义

Detection and clinical application of D-dimer in plasma of primary hypertension

目的探讨高血压患者血浆D-二聚体浓度与高血压及靶器官损害的关系及临床意义。方法收集本院心内科门诊及住院的76例不同病期的高血压患者及45名正常者的血浆,根据高血压患者心血管危险分层标准以区分靶器官的损害程度,用ELISA法检测76例高血压患者及45名正常对照者的血浆例正常对照者的血浆D-二聚体。用完全随机设计多组均数比较的方差分析、dunnet-t法及Student-Newman-Keruls法进行统计分析。结果正常对照组与高血压组患者的血浆D-二聚体浓度比较,差异有统计学意义(F=4.32,P<0.01),各组与标准组之间分析显示(采用dunnet-t法):极高危组、高危组均与标准组比较,差异有明显统计学意义,两两比较结果显示(采用SNK法、即:Student-Newman-Keruls法):高危组与极高危组均与中危组及标准组差异有统计学意义。结论因极高危组与高危组高血压患者的D-二聚体含量较标准组存在显著的差异,而极高危组与高危组高血压又与靶器官的损伤有关,因此血浆D-二聚体浓度可以作为临床上判断高血压病严重程度及靶器官损害程度的一项指标。

Objective Analyze the density of D-dimer in plasma of primary hypertension and clinical application. Methods Collected blood from 76 patients of deferent stage of primary hypertension and 45 norreal people , detecting D-dimer in plasma by ELISA. Analysis the data by analysis of variance , dunnet-t and Student- Newman-Keruls. Results Significant deviation between normal control group and primary hypertension group , analysis of dunnet-t showing ： significant deviation between highest-risk group and normal control group ;between higher-risk group and normal control group. Analysised of SNK showing ： significant deviation between highest-risk group, higher-risk group and high-risk group, normal control group. Conclusion The density of D-dimer in plasma of primary hypertension can use as a index to analyze different primary hypertension and damaging degree of target organs.