肺静脉前庭在犬心房颤动中的作用

Role of the pulmonary vein antrum in atrial fibrillation in canines

目的测定诱发心房颤动(AF)或持续电刺激2h前后肺静脉前庭有效不应期(ERP),探讨其在AF中的作用。方法健康杂种犬10只,S1S2程序刺激测定窦性心律下和诱发AF或持续电刺激2h后肺静脉前庭ERP;并进行AF诱发,并记录AF的发生。结果肺静脉前庭ERP在诱发AF或持续电刺激2h后与窦性心律下相比差异有统计学意义(P<0.05)。诱发AF或持续电刺激2h后AF诱发率增加(24.38% VS 9.68%,P<0.05)。结论诱发AF或持续电刺激2h后可以使肺静脉前庭ERP缩短且更易诱发AF,肺静脉前庭在AF中起着重要作用。

Objective To determine effective refractory periods （ERPs） of the pulmonary vein antrum before and after atrial fibrllaton/sfimulaton 2 hours and approach the role of pulmonary vein antrum in atrial fibrillation in canines. Methods The ERPs of the pulmonary vein antrum were measured by S1S2 programmed stimulation in the same condition （ sinus rhythm and atrial fibriUation/stimulation 2 hours）. AF was induced by S1S2 programmed stimulation and recorded on ECG. Results After atrial fibrillation/stimulation 2 hours, the difference was significant as compared with the data of sinus rhythm （ P 〈 0.05 ）. And the inducible rate of AF had distinctly difference （24. 38% VS 9.68%, P 〈0. 05 ）. Conclusion After atrial fibrillation/stimulation 2 hours, the ERPs of the pulmonary vein antrum were shorter and the AF inducibility is higher. The pulmonary vein antrum play a more important role in the incidence of AF.