运动与肾素─血管紧张素系统(文献综述)

Sport and RAS(an overview)

近年来随着生物化学和分子生物学技术的发展，人们发现除了经典的肾素一血管紧张素系统（ＲＡＳ）对机体的水、电解质等平衡进行调节外，在心血管系统还存在局部ＲＡＳ，可自身合成、释放肾素和血管紧张素（ＡＧＴ），在高血压、心肌缺血、心肌肥厚、心肌梗塞和心律失常等疾病的发生上具有重要作用。总结了经典和局部ＲＡＳ的机制及作用，并对运动与ＲＡＳ的关系进行综述。由于运动可激活ＲＡＳ，我们是否可以间接地推测：在剧烈运动对心脏的影响中，ＲＡＳ起到某种损害作用？因此对运动与ＲＡＳ进行深入的研究有助于揭示大强度运动引发心脏损害的机制以及应用ＡⅡ转换酶抑制剂能否减轻心脏损害等问题，具有重大的实际意义。

With the recent development of the biochemical and molecule biological technique it has beenfound that besides the regulation of the water and dielectric balance in the body by the classical renin-an-giotensin system(RAS),in the cardiovascular system there is a partial RAS,which itself is able to synthesize , release renin and angiotensin(AGT),which are the important factors to lead to diseases, such as thehypertension, myocardial ischemia, hypertrophy, infarct and arrhythmia of pulse etc. In this paper themechanism and effects of the classical RAS and the partial RAS were summarized and the relationships between sport and RAS were summed up. Since sport activates RAS, can we indirectly infer that during intensive exercises RAS injures the heart? Therefore, a thorough study on sport and RAS contributes to revealing such problems as the mechanism of the heart injury, caused by intensive exercises and whether A IItransferase inhibitor reduces injury of the heart and so on. It is of practic al importance.