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HLA-DRB1基因与湘西土家、汉族人群不明原因反复流产的相关性研究

Study on the correlation between HLA-DRB1 genes and unexplained recurrent spontaneous abortions in Xiangxi Tujia and Han population
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摘要 目的探讨HLA-DRBI基因多态性与湘西土家族、汉族人群不明原因反复流产(URSA)的遗传关联性。方法采用聚合酶链反应一序列特异性引物(PCR—SSP)技术,对76例湘西土家族、68例汉族人群URSA患者和82例湘西土家族、75例汉族人群健康对照者的HLA-DRB1等位基因进行分析。结果①土家族、汉族URSA组的DRB1* 04基因频率显著高于土家族及汉族对照组(RR〉1,Pc〈0.01);DRB1* 12的基因频率显著低于对照组(RR〈1,P,〈0.01)。②土家族URSA组的DRBl*07基因频率明显高于汉族URSA组(18.08%比5.28%,Pc〈0.01)。结论HLA-DRBI* 04可能是湘西土家族、汉族人群不明原因反复流产的易感基因.HLA-DRB1 *12可能为保护基因。 Objective To analyze the HLA- DRB1 gene polymorphism and the hereditary association with unexplained recurrent spontaneous abortions ( URSA ) in a population of Tujia and Han nationality from west part of Hunan province in China. Methods The alleles at the HLA-DRB1 typing were analyzed by polymerase chain reaction-sequence specific primers ( PCR-SSP ) in 76 URSA Tujia population and 68 URSA Han population and 82 healthy Tujia population and 75 healthy Han population. Results ①DRB1 * 04 frequency of URSA in Tujia and Han population was strikingly higher than that of the healthy Tujia and Han population ( RR 〉 1, Pc 〈 0.01 ), but the DRBI * 12 frequency was strikingly lower than that of the healthy Tujia and Han population respectively( RR 〈 1 ,Pc 〈0.01 ). ②DRB1 * 07 frequency of URSA in Tujia population was strikingly higher than that of the URSA in Han population 118.08% :5.28%, Pc 〈 0. 01 ). Conclusion HLA-DRB1 * 04 maybe predisposing genes of URSA in Tujia and Han population,and HLA-DRB1 * 12 maybe associated with an antagonist effect in the pathogenesis of URSA in this population.
出处 《中国综合临床》 北大核心 2008年第12期1226-1228,共3页 Clinical Medicine of China
基金 湖南省教育厅资助科研项目(05C131) 湖南省湘西自治州科技计划项目(2005CXZ13)
关键词 流产 HIA-DR基因 土家族 Abortion HLA-DRB1 gene Tujia Minority
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参考文献5

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