地震后重灾区与轻灾区乳腺癌患者血清有机氯农药残留物水平研究

Study on serum organochlorine pesticides and residues levels in breast cancer patients between the seriously and lightly earthquake-striken areas

目的分析唐山地震重灾区与轻灾区乳腺癌患者血清有机氯农药残留物水平。方法收集唐山市重灾区乳腺癌患者93例，轻灾区65例，采用附ECD检测器的气相色谱仪检测其血清中有机氯农药（DDTs和HCHs）含量并比较其差异。结果两地区研究对象血清中有机氯农药残留物含量均不呈正态分布。重灾区和轻灾区乳腺癌患者血清中各种六氯环已烷（HCH）异构体检出率顺序为β-HCH〉6-HCH〉α-HCH〉γ-HCH。重灾区和轻灾区乳腺癌患者血清中DDT各异构体其检出率顺序为PP＇-DDE〉PP＇-DDT〉OP＇-DDT〉pp＇-DDD。重灾区与轻灾区乳腺癌患者血清中α-HCH、β-HCH、PP’-DDE和PP＇-DDD含量差异有统计学意义。结论重灾区乳腺癌患者血清中高检出率的有机氯农药残留物含量高于轻灾区，可能与重灾区有机氯农药高暴露有关。

Objective To evaluate serum organochlorine pesticides and residues levels in breast cancer patients between the seriously and lightly earthquake-striken areas of Tangshan. Methods 93 patients of breast cancer from seriously earthquake-striken areas and 65 patients from lightly earthquake-striken areas were selected as study subjects, which serum organochlorine pesticides （DDTs and HCHs ） levels were detected and compared with gas chromatography/electron capture. Results Serum organochlorine pesticides and residues levels in 158 patients between the seriously and lightly earthquake-striken areas of Tangshan were not normal distributed. The order of detection rate of HCH isomer in breast cancer patients between the seriously and lightly earthquake-striken areas were β- HCH 〉 δ-HCH 〉 α-HCH 〉 γ-HCH. The orders of detection rate of DDT isomer in breast cancer patients between two areas of Tangshan were PP＇-DDE 〉 PP＇-DDT 〉 OP＇-DDT 〉 PP＇-DDD. The serum levels of α-HCH, β-HCH, PP＇-DDE and PP＇-DDD in breast cancer patients between the seriously and lightly earthquake-striken areas were statistically different. Conclusion The levels of organochlorine pesticides and residues in serum with high detection rate in seriously earthquake-striken area are higher than that in lightly earthquake-striken area. It is likely that there is an association with a large number of organochlorine pesticides sprayed.