性激素和降钙素基因相关肽对围绝经期妇女潮热症状的影响

Effect of the levels of serum gonadal hormone and plasma calcitonin gene-related peptide on the hot flushes symptom of perimenopausal women

目的探讨围绝经期妇女血清性激素和血浆降钙素基因相关肽（CGRP）水平对潮热症状的影响。方法将65例围绝经期妇女分为有潮热症状组35例、无潮热症状组30例，25例健康育龄妇女为育龄对照组；均进行血清雌二醇（E2）、促卵泡生成素（FSH）、促黄体生成素（LH）和血浆CGRP含量的测定。结果①潮热组与无潮热组血清E2水平比较差异无统计学意义（P〉0．05），潮热组FSH、LH水平高于无潮热组和育龄对照组，差异有统计学意义（均P〈0．05）；②潮热组CGRP水平高于无潮热组，低于育龄组，差异均有统计学意义（P〈0．05）；③轻度、中度潮热妇女CGRP水平明显低于重度潮热者，差异有统计学意义（P〈0．05）；潮热严重程度与CGRP呈正相关（r=0．823，P〈0．01），与E2水平无相关性（rs=-0．258，P〉0．05）。结论围绝经期妇女潮热症状的发生与血循环中雌激素水平的下降及波动性变化，FSH、LH升高，CGRP浓度变化密切相关。

Objective To study the effect of the levels of serum gonadal hormone and plasma calcitonin gene-related peptide（CGRP） on the hot flushes symptom of perimenopausal women. Methods 65 perimenopausal women （35 with hot flushes and 30 without hot flushes） and 25 healthy fertile women were enrolled. The subjects were analyzed for serum estradiol （ E2 ）, follicle-stimulating hormone （ FSH） , luteinizing hormone （ LH ） and plasma calcitonin gene-related peptide （CGRP）. Results ① There were no significant differences of the E2 levels between the perimenopausal women with and without hot flushes （ P 〉 0.05 ）. The levels of FSH and LH were significantly higher in the women with hot flushes than women without hot flushes and fertile women（ P 〈 0.05 ） ,② The levels of plasma CGRP were significantly higher in the women with hot flushes than women without hot flushes （ P 〈 0.05 ） , and significantly lower than fertile women,③The levels of plasma CGRP were significantly higher in severe hot flushes group than that in the mild hot flushes group and moderate hot flushes group （ P 〈 0.05 ） , the severity of hot flu-shes was positively related to the level of plasma CGRP（ r, = 0. 823 ,P 〈 0.01 ）, but there was no relationship between serum E2 and the severity of hot flushes （ P 〉 0.05 ）. Conclusion The occurrence of perimenopausal hot flu- shes might be closely related to the decline and fluctuation of serum E2 ,increase of FSH and LH and the concentration variety of plasma CGRP.