来曲唑联合二甲双胍对多囊卵巢不育患者的临床疗效观察

Efficacy of combined metformin-letrozole in comparison with letrozole alone in infertile women with polycystic ovarian syndrome

目的：观察比较对于多囊卵巢综合征（Polycysticovariansyndrome，PCOS）的不育患者，来曲唑（1etrozole，LE）联合二甲双胍与LE单独应用的临床疗效。方法：PCOS的不育患者39例，其中19例经过二甲双胍治疗6～8个星期后采用LE促排卵治疗，另外20例直接采用LE治疗，比较LE治疗3个周期后两组的妊娠率。结果：LE联合二甲双胍治疗组妊娠率较高（47．04％VS15％，P=0．029）。结论：对于PCOS不育患者，LE联合二甲双胍治疗的妊娠率更高。

Objective To investigate the therapeutic effect of combined metformin - letrozole in comparison with letrozole alone in in- fertile women with polycystic ovarian syndrome （PCOS）. Method Infertile women with PCOS were randomly divided into metformin - letrozole group （ n = 19） and letrozole group （ n = 20）. After an initial 6 - 8 weeks＇ treatment of mefformin in metformin - letrozole group, followed by letrozole （5 mg） from day 3 -7 of menstrual cycle. Letrozole group received letrozole treatment alone. After 3 menstrual cy- cles, pregnancy rates were compared between the two groups. Results The pregnancy rate in metformin - letrozole group was significantly higher than letrozole group （47.04% vs 15%, P =0.029）. Conclusion In PCOS patients, the combination of letrozole and metformin leads to higher pregnancies.