胰岛素联合非磺脲类药物治疗磺脲类药物失效的2型糖尿病40例临床分析

Clinically comparison insulin combining oral drug for treating diabetes Ⅱ patients' sulfonylureas druggery inactivation

目的:观察人胰岛素联合非磺脲类口服药物治疗口服磺脲类药继发失效的2型糖尿病的临床效果。方法:选择2型糖尿病磺脲类药物继发失效病人40例,随机分3组:A组采用优泌乐25单纯胰岛素治疗;B组采用优泌乐25加二甲双胍;C组采用优泌乐25加拜糖苹,治疗后观察4周。结果:3组治疗后空腹和餐后2小时血糖较治疗前显著降低(P均<0.05);B组、C组血糖达标的时间及最后每日胰岛素用量与A组比较差异有统计学意义(P<0.05)。结论:在人胰岛素治疗时,联合应用非磺尿类口服药有利于血糖控制、减少胰岛素用量和缩短血糖达标时间。

Objective： To observe diabetes Ⅱ patients＇ sulfonylureas druggery inactivation changing intousing Humalog Mix25 combining non-sulfonylureas oral drug. Methods： To divide patients with diabetesⅡ sulfonylureas inactivation into team A, B and C. Patients of team A were treated by Humalog Mix25, patients of team B were treated by Humalog Mix25 adding dimethylbiuamide; patients of team C were treated by 25 adding acarbose. Treating for weeks and observed them. Result： Three ways all can make sugar blood low （P〈0.05） ; about the time of blood sugar reaching the standard of team B and C, the final daily insulin dosage is more obvious than team A （P〈0. 05）. Conclusion： When treating with Humalog Mix25, combining non-sulfonylureas oral drug can help to control the blood sugar, reduce the dosage of the insulin and shorten the time of blood sugar reaching the standard.