复方胡芦巴对小鼠化学性肝损伤的影响

Influence of compound Trigonella foenum-graecum.L against acute chemical liver injury in mice

目的:探讨复方胡芦巴对四氯化碳(CCl4)所致小鼠化学性肝损伤的保护作用。方法:经预防给药10 d后,采用CCl4复制小鼠急性肝损伤模型,16 h后眼眶取血,测定小鼠血清中丙氨酸氨基转移酶(ALT))和门冬氨酸氨基转移酶(AST)含量,观察肝脏病理组织学变化。结果:复方胡芦巴大、中剂量能明显降低CCl4所致肝损伤动物模型的血清AST含量(P<0.05),且可改善CCl4引起的肝脏组织的病理变化,对动物体重变化无影响(P>0.05)。结论:复方胡芦巴对CCl4所致小鼠化学性肝损伤具有明显的保护作用。

Objective： To explore the protective effects of compound Trigonella foenum-graecum. L against carbon tetrachloreide （CCl4） induced acute chemical liver injury in mice. Methods： Pretreated with compound Trigonella foenum-graecum. L for 10 days,mice model of the acute liver injury were established by the treatment of carbon tetrachloride （CCl4）, 16 hours later, the protective effects of compound Trigonella foenum-graecum. L in acute chemical liver injury induced by carbon tetrachloreide （CCl4） were observed through determining the activiteds of alanine aminotransferase （ALT） and aspartate aminotransferase （AST） in serum,histopathological changes of liver were also observed. Results： Compound Trigonella foe- num-graecum. L significantly decreasde the contents of serum ALT in CCl4-induced liver injury model mice （compared with model group, P〈0.05）, and the pathologica changes induced by CCl4 in liver tissues were improved. There was no significant difference in the effects of weight of animals （P〉0.05）. Conclusions： Compound Trigonella foenum-graecum. L plays the protective effects obviously on acute chemical liver injury induced by CCl4 in mice.