肾素基因rs5705变异与降压药物作用下血压及相关临床表型变化的关系

The association of REN variation and the response of blood pressure and related clinical phenotypes under antihypertensive drugs in Kazak

目的:探讨新疆哈萨克族原发性高血压患者肾素基因rs5705基因型与研究对象服用降压药物前后血压及相关临床表型(包括肾素、血管紧张素Ⅱ及醛固酮)水平变化的关系。方法:随机选择新疆18～69岁1 218名哈萨克族农牧民进行高血压相关危险因素横断面调查,筛选出首次诊断为高血压并未接受过降压治疗和无其他并发症的400人作为研究对象。随机分为2组,分别服用血管紧张素转换酶抑制剂卡托普利和β受体阻滞剂阿替洛尔。2组均服药3周,应用聚合酶链式反应-连接酶检测反应检测研究对象肾素基因rs5705基因型,分析其与服用降压药物前后研究对象血压及相关临床表型水平变化的关系。结果:肾素基因rs5705经Hardy-Weinberg遗传平衡检验平衡;未发现肾素基因rs5705基因型与收缩压、舒张压、血浆肾素、血管紧张素Ⅱ和醛固酮用药前后水平变化有关。结论:新疆哈萨克族原发性高血压患者肾素基因rs5705基因型与收缩压、舒张压、血浆肾素、血管紧张素Ⅱ和醛固酮用药前后变化无关。

Objective： To study the relationship between REN rs5705 different genotypes and response of blood pressure and related clinical phenotypes under antihypertensive drugs in Xinjiang Kazak. Methods： In total randomly selected 1218 Kazaks aged 18-69 years were investigated for hypertension and risk factors in Xinjiang. First-diagnosed hypertensive patients （n =400） without antihypertensive medical history and complications were recruited for the current trial. All recruited subjects were randomly divided into two groups and received captopril and atenolol treatment respectively for three weeks. The polymorphism REN rs5705 were genotyped in these subjects by using polymerase chain reaction-ligase detection reaction （PCR-LDR）. To study the relationship between REN rs5705 different genotypes and response of blood pressure and related clinical phenotypes（plasma renin, Angiotensin Ⅱ , aldosterone） under antihypertensive drugs. Results：The genotype frequency of REN rs5705 was in Hardy-Weinberg equilibrium. We didn＇t find any relationship of rs5705 genotypes and the changes of systolic blood pressure, diastolic blood pressure, plasma renin, angiotensin Ⅱ or aldosterone after medication. Conclusion： The results suggest that the genotypes rs5705 of renin gene might not be associated with the effect of antihypertensive treatment by captopril and atenolol in Xinjiang Kazak.