我院2003～2007年住院患者头孢菌素类药应用情况分析

DDDs of Cephalosporins per 1000 Patients/day in Our Hospital During 2003～2007

目的:评价我院住院患者头孢菌素类药的使用情况及趋势。方法:对我院2003～2007年头孢菌素类药的品种、用药金额、用药频度(DDDs)、应用密度(AUD)及日均费用(DDC)等进行统计、分析。结果:5年中,我院头孢菌素类药DDDs、DDC、AUD的年均增长率分别为26.56%、2.84%、13.08%。其中,口服头孢菌素类药的AUD年均增长率略高于注射用头孢菌素类药;第3代头孢菌素类药各年度DDDs与AUD最大,其AUD比例在50%～70%之间波动;第4代头孢菌素类药的DDDs和AUD年均增长率分别为106.35%、84.37%,增长最快。结论:第3代头孢菌素类药的AUD最大,第4代头孢菌素类药的AUD剧增。为延缓细菌耐药的产生,应进一步规范管理头孢菌素类药的应用。

OBJECTIVE： To evaluate the utilization and tendency of eephalosporins in our hospital. METHODS： The eephalosporins used in Southwest Hospital during 2003-2007 were statistically analyzed in respect of the variety, consumption sum, DDDs, AUD （Antimicrobial Use Density）. RESULTS： During the 5 years, the annual increase rates of DDDs, DDC and AUD of cephalosporins were 26.56% , 2.84% , and 13.08% , respectively. The annual increase rate of AUD of oral cephalosporins was a little bit higher than that of eephalosporins for injection. The third generation cephalosporins took the lead in terms DDDs and AUD at each year, with its AUD ranged between 50% and 70%;： the annual increase rates in DDDs and AUD of the fourth generation eephalosporins were the highest at 106.35% and 84.37% respectively. CONCLUSION： The third generation cephalosporins dominated the first place in term of AUD. The AUD of the fourth generation cephalosporins increased sharply. In order to delay the bacterial drug resistance, it isvery important to further standardize the use of cephalosporins.