摘要
目的:考察注射用头孢哌酮钠/舒巴坦钠与注射用多索茶碱在0.9%氯化钠注射液中的配伍稳定性。方法:采用紫外双波长分光光度法测定(25±1)℃条件下放置6h内配伍液中2组分含量,并比较配伍前、后其外观、pH值的变化。结果:配伍后多索茶碱含量无明显变化,头孢哌酮钠/舒巴坦钠含量略有下降,其余考察指标无显著性变化。结论:注射用头孢哌酮钠/舒巴坦钠与注射用多索茶碱可在0.9%氯化钠注射液中配伍应用,但应在25℃条件下4h内使用完毕。
OBJECTIVE: To study the compatible stability of doxofylline for injection with cefoperazone sodium/sulbactam sodium for Iniection. METHODS: The contents of 2 constituents in the mixed solution stored at (25 ± 1)℃ within 6 hours were determined by dual ultraviolet wavelength spectrophotometry, and the appearance and pH value of the mixture were compared with those before mixing. RESULTS: There was no significant change in the content of doxofylline after mixing, while the contents of cefoperazone sodium and sulbactam sodium showed a slight reduction. No significant change was noted for other indexes. CONCLUSION: Doxofylline injection is compatible with cefoperazone sodium and sulbactam sodium for injection in 0.9% sodium chloride injection at 2512 within 4 hours' mixing.
出处
《中国药房》
CAS
CSCD
北大核心
2008年第35期2762-2764,共3页
China Pharmacy
关键词
头孢哌酮钠/舒巴坦钠
多索荼碱
稳定性
紫外双波长分光光度法
配伍
Cefoperazone sodium/ sulbaetum sodium
Doxofylline
Stability
Dual ultraviolet wavelength spectrophotometry
Mixing