注射用头孢哌酮钠/舒巴坦钠与多索茶碱的配伍稳定性考察

Sompatible Stability of Cefoperazone Sodium/Sulbactam Sodium for Injection Mixing with Doxofylline for Injection

目的:考察注射用头孢哌酮钠/舒巴坦钠与注射用多索茶碱在0.9%氯化钠注射液中的配伍稳定性。方法:采用紫外双波长分光光度法测定(25±1)℃条件下放置6h内配伍液中2组分含量,并比较配伍前、后其外观、pH值的变化。结果:配伍后多索茶碱含量无明显变化,头孢哌酮钠/舒巴坦钠含量略有下降,其余考察指标无显著性变化。结论:注射用头孢哌酮钠/舒巴坦钠与注射用多索茶碱可在0.9%氯化钠注射液中配伍应用,但应在25℃条件下4h内使用完毕。

OBJECTIVE： To study the compatible stability of doxofylline for injection with cefoperazone sodium/sulbactam sodium for Iniection. METHODS： The contents of 2 constituents in the mixed solution stored at （25 ± 1）℃ within 6 hours were determined by dual ultraviolet wavelength spectrophotometry, and the appearance and pH value of the mixture were compared with those before mixing. RESULTS： There was no significant change in the content of doxofylline after mixing, while the contents of cefoperazone sodium and sulbactam sodium showed a slight reduction. No significant change was noted for other indexes. CONCLUSION： Doxofylline injection is compatible with cefoperazone sodium and sulbactam sodium for injection in 0.9% sodium chloride injection at 2512 within 4 hours＇ mixing.