注射用血凝酶在鼻内镜手术中对出血量和凝血功能的影响

Effects of Ophidiase for Injection on Blood Loss and Blood Coagulation Function in Patients Undergoing Endoscopic Sinus Surgery

目的:观察注射用血凝酶在鼻内镜手术中的止血效果。方法:将80例行鼻内镜下鼻息肉摘除手术患者随机分为2组,观察组采用入手术室后即肌肉注射血凝酶1KU,术中静脉注射血凝酶2KU;对照组注射相同容量生理盐水。比较2组患者术中出血量及凝血功能指标的变化。结果:对照组平均出血(198.8±1.73)mL,观察组平均出血(126.3±1.02)mL,观察组平均出血量较对照组减少(72.5±0.51)mL,差异有统计学意义(P<0.05);与观察组比较,对照组手术结束时凝血酶原时间和活化部分凝血活酶时间明显延长(P<0.01)。结论:在鼻内镜手术中,术前肌肉注射及术中静脉注射血凝酶止血效果好,出血量少。

OBJECTIVE： To observe the hemostatic effect of Ophidiase for Injection in patients undergoing endoscopic sinus surgery. METHODS： 80 patients undergoing endoscopic nasal polypectomy were divided into two groups randomly： the experiment group was injected i.m. with 1 KU Ophidiase for injection before operation and infused iv with 2 KU Ophidiase for injection during operation, while the control group was injected with the same volume of physiological saline at the corresponding time. The blood loss and the blood coagulation function in the two groups were compared. RESULTS： There were significant differences between the control group and the experiment group in the average blood loss. （198.8 ± 1.73 mL vs. 126.3 ± 1.02 mL） （P 〈 0.05）, 72.5± 0.51 mL less in the experiment group than in the control group. As compared with the experiment group, both the pro - time and the activated partial thromboplastin time in the control group after the completion of surgery were significantly longer （P〈0.01） . CONCLUSION： Administered i.m. before operation plus iv during operation, Ophidiase for injection showed remarkable efficacy in hemostasis and blood loss reduction in patients undergoing endoscopic sinus surgery.