我院618例药品不良反应报告分析

Adverse Drug Reactions:Analysis of 618 Cases in Our Hospital

目的:探讨我院药品不良反应(ADR)发生的规律及特点。方法:收集我院2005～2006年通过网络系统向国家ADR数据库上报的ADR报表618份,按患者性别、年龄、因果评级及转归、临床表现、给药途径及涉及药品等进行分类、统计和分析。结果:抗感染药ADR发生率居首位,其次为抗肿瘤药、中成药;临床表现主要为药物性皮疹、过敏、哮喘,其次为胃肠道反应,骨髓抑制、白细胞减少与休克等严重不良反应发生较少。结论:ADR监测存在一定程度的不足,应当加强ADR监测力度及其相关知识的宣传,从而指导临床合理、安全、有效用药。

OBJECTIVE： To discuss the characteristics and regularities of adverse drug reactions （ADR） in our hospital. METHODS： ADR reports of 618 cases collected via ADR network system and submitted to state ADR database from 2005 to 2006 were analyzed statistically in respect of patients＇ age and sex, rating of correlated factors and outcome, clinical manifestations, routes of administration, and the involved drugs etc. RESULTS： Anti- infective drugs dominated the first place on the list of ADR incidence rate, followed by antineoplastic agent and Chinese patent medicines. The main symptoms of ADR were drug eruption, allergic, athma, followed by gastrointestinal reaction. There were fewer incidences of serious ADR such as bone marrow depression, hypoleukemia and shock. CONCLUSION： The ADR monitoring in Fuzhou General Hospital is lack and should be strengthened, and knowledge of ADR must be publicized for guiding the rational, safe and effective drug use in clinic.