某院1998-2007年预防接种不良反应分析

Analysis on Adverse Reactions After Prophylactic Vaccination in A Hospital From 1998 to 2007

目的分析某院1998-2007年接种门诊报告的预防接种不良反应,了解不良反应发生频率,探讨防控不良反应措施。方法根据临床症状将预防接种不良反应分为一般反应、异常反应、偶合反应,对其发生原因等进行统计分析。结果1998-2007年某院共开展16种疫苗108638人次的接种,有9种疫苗发生不良反应87例,其中一般反应74例,异常反应12例,偶合反应1例。不良反应以弱、中度局部红肿、低热等为主要表现。全细胞百白破疫苗(DTwP)不良反应报告发生率最高(381.30/10万接种人次),且随接种针次的增加而增高。结论严格掌握接种禁忌症,规范化操作,选用安全性高免疫效果好的疫苗,能够预防和减少不良反应的发生。

Objective To analyse the adverse reactions and tients from 1998 to 2007. Method According to clinical frequency after prophylactic vaccination in out-pasymptoms, the adverse reactions were divided into common reation, abnormal reaction and coupling reaction. Results From 1998 to 2007, a total of 108 638 person-times vaccinated with 16 kinds of vaccine, in which 9 kinds of vaccine induced adverse reactions among 87 persons i. e. common reaction 14 persons, abnormal reaction 12 persons and coupling reaction 1 person. The main manifestations of adverse reaction were local weak or medium red and swollen, slight fever etc. DTwP induced the righest adverse reaction rate of 469. 14/105 person-times. The adverse reaction rate increased along with the vaccination times. Conclusion It is necessary to control the vaccination induced adverse reaction by mastering strictly the vaccination contraindicatioos, operating formaly and selecting vaccine with high safety and effectiveness.