石斛对实验大鼠慢性萎缩性胃炎御炎机制的研究

The anti-inflammatory mechanism of dendrobium decoction on models of experimental chronic atrophic gastritis in rats

目的探讨石斛对慢性萎缩性胃炎(CAG)的防治机制,为临床提供实验依据。方法用氨水、乙醇和去氧胆酸钠灌胃法,制成大鼠CAG模型。造模后治疗组以石斛煎剂治疗5周,观察CAG胃黏膜血流量和前列腺素E2(PGE2)的变化情况。并与模型组和对照组比较。结果治疗组和模型组建模后(治疗前)其胃黏膜血流量和PGE2含量均较对照组低(P均<0.01)。治疗组经石斛治疗5周后,其胃黏膜血流量较模型组高(P<0.01),与对照组比较差异无显著性(P>0.05);治疗组PGE2含量较模型组高(P<0.01),与对照组比较差异无显著性(P>0.05)。结论石斛可以改善实验大鼠CAG的胃黏膜血流量,提高其PGE2含量,提示其对CAG大鼠的胃黏膜有提高其屏障功能和御炎作用,对CAG有防治作用。

Objective To investigate the anti - inflammatory mechanism of dendrobium decoction on models of experimental chronic atrophic gastritis （CAG） in rats and to provide um decoction. Methods The CAG models in rats were produced laboratory evidences for clinical use of dendrohiby intragastric ammonia water, ethanol and deoxysodium cholate infusion. The model rats were given dendrobium decoction for five weeks. The measurement of gastric mucosa blood flow volume and prostaglandin E2（PGF2） was conducted and a comparison of these two indices among the therapeutic group, the model group and the control group was performed. Results Gastric mucosa blood flow volume and PGE2 for the therapeutic group and the model group （before drug administration） decreased significantly than that for the control group （all P 〈0.01）. 5 weeks after dendrobium decoction, the gastric mucosa blood flow volume for therapeutic group was lower than that for model group （ P 〈0.01）, in comparison to the control group, there was no significant difference （ P 〉0.05）. PGE2 for the therapeutic group was higher than that for the model group（ P 〈0.01）, in comparison to the control group, there was no significant difference （ P 〉0.05）. Conclusion Dendrobium decoction can lower down gastric mucosa blood flow volume in models of experimental CAG in rats and up - regulate PGFe. The data indicated that Dendrobium decoction can enhance the barrier action of gastric mucosa in models of CAG in rats and have the anti - inflammatory and preventive function.