白细胞介素-1(IL-1)在中枢神经系统中的作用

EFFECTS OF IL-1 ON CENTRAL NERVOUS SYSTEM

自细胞介素—1是分子量为17kD的主要由免疫细胞产生的一种细胞因子。一般认为它主要介导非特异性免疫反应和调节免疫系统的功能。但近年来研究发现．IL—1及其受体也存在于中枢神经系统。它做为一种神经递质、神经调质或生长因子参与了中枢神经系统的生理及病理活动变化。本文综述了IL—1在中枢神经系统的生理及病理作用。

Interleukin-l (IL-l), a 17 kD cytokine mainly produced by immunocytes, mediatesnon－specfic immune reactions and regulates functions of immune system. According to recent studies, IL-l andits receptors were also found in the central nervous system (CNS). IL-l acting as a neurotransmittet,neuromodulator/ growth factor, is involved in normal Physiological processes and pathogenesis of diseases in theCNS. In this review, we summarized Physiological and pathological effectS of IL-1 in the CNS.